A Microcirculatory Theory of Aging

dc.creatorJin, Kunlin
dc.creator.orcid0000-0002-1336-348X (Jin, Kunlin)
dc.date.accessioned2022-09-09T14:08:42Z
dc.date.available2022-09-09T14:08:42Z
dc.date.issued2019-06-01
dc.description.abstractAging is the progressive decline of physiological functions necessary for survival and reproduction. In gaining a better understanding of the inevitable aging process, the hope is to preserve, promote, or delay healthy aging through the treatment of common age-associated diseases. Although there are theories that try to explain the aging process, none of them seem to fully satisfy. Microcirculation describes blood flow through the capillaries in the circulatory system. The main functions of the microcirculation are the delivery of oxgen and nutrients and the removal of CO2, metabolic debris, and toxins. The microcirculatory impairment or dysfunction over time will result in the accumulation of toxic products and CO2 and loss of nutrition supplementation and O2 in corresponding tissue systems or internal organs, which eventually affect normal tissue and organ functions, leading to aging. Therefore, I propose a microcirculatory theory of aging: aging is the process of continuous impairment of microcirculation in the body.
dc.description.sponsorshipThis work was supported by National Institute of Health (NIH) grant R21NS094859 and American Heart Association grant 14GRNT20480178.
dc.identifier.citationJin K. (2019). A Microcirculatory Theory of Aging. Aging and disease, 10(3), 676-683. https://doi.org/10.14336/AD.2019.0315
dc.identifier.issn2152-5250
dc.identifier.issue3
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31703
dc.identifier.volume10
dc.publisherJKL International
dc.relation.urihttps://doi.org/10.14336/AD.2019.0315
dc.rights.holder© 2019 Jin K et al.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceAging and Disease
dc.subjectaging
dc.subjectimpairment
dc.subjectlifespan
dc.subjectmicrocirculation
dc.subjecttheory
dc.titleA Microcirculatory Theory of Aging
dc.typeArticle
dc.type.materialtext

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