Dyslipidemia in Hispanic Prediabetics with Mild Cognitive Impairment

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2024-03-21

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0000-0002-3430-5019 (Koester, Paul)

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Purpose: Prediabetes or impaired glucose tolerance affects an estimated 96 million adults in the United States and may be a modifiable risk factor for cognitive impairment. Several studies have shown that prediabetics experience poorer longitudinal cognitive outcomes compared to non-diabetics; however, the exact mechanism is still a matter of debate. Furthermore, prediabetic patients often experience metabolic syndrome-related comorbidities like dyslipidemia that may be related to in the development and progression of cognitive impairment in prediabetic patient populations. The aim of this study was to examine the relationship between lipid levels between ethnic groups in prediabetic, mildly cognitively impaired, Hispanics, Non-Hispanic Whites, and African Americans. Methods: Data from 144 mildly cognitively impaired prediabetic participants (Hispanics, Non-Hispanic Whites, and African Americans) was collected and analyzed from the Health and Aging Brain Study: Health Disparities (HABS-HD), a community-based epidemiological study of aging. Participants of the study undergo cognitive and functional testing, as well as brain imaging (MRI and PET). Basic demographic information is also collected, and blood samples are used to determine HbA1c, fasting blood glucose, and lipid profiles. One-way ANOVAs examined differences in total cholesterol, triglyceride, and LDL measurements based on ethnicity. Results: Results showed significant differences in total cholesterol levels between the Hispanic (M = 193.98, SD = 38.17), non-Hispanic white (M = 169.54, SD = 37.26), and African American (M = 170.41, SD = 35.52) populations (F = 7.20, p <0.001), triglyceride levels between the Hispanic (M = 154.25, SD = 80.47), non-Hispanic white (M = 124.62, SD = 50.81), and African American (M = 95.17, SD – 57.77) populations (F = 10.96, p<0.000), and LDL levels between the Hispanic (M = 111.86, SD = 31.88), non-Hispanic white (M = 95.62, SD = 29.91), and African American (M = 94.77, SD = 27.38) populations (F = 5.37, p<0.006). Conclusion: Prediabetic Hispanic participants in the study with MCI were shown to have higher lipid profiles (triglycerides, LDL, and total cholesterol) as compared to non-Hispanic white and African American participants. Future studies should further examine the relationship between prediabetes and dyslipidemia, including clinical outcomes regarding the treatment of elevated lipids.

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