Determination of Genetic Factors Associated with Response to Osteopathic Manipulative Treatment (OMT) in Individuals with Chronic Lower Back Pain (CLBP).

dc.contributor.advisorDeanna Cross
dc.creatorRichardson, Kayla K.
dc.date.accessioned2019-08-22T21:02:28Z
dc.date.available2019-08-22T21:02:28Z
dc.date.issued2014-05-01
dc.date.submitted2014-05-22T08:00:05-07:00
dc.description.abstractOMT is a treatment for patients with CLBP. It is underutilized partially because there is still skepticism regarding efficacy and no clear mechanism of action has been defined. Data previously collected from a CLBP clinical study was used to investigate genotypic and/or phenotypic characteristics associated with OMT pain reduction. Polymorphisms in IL-8 (rs2227543), GCH1 (rs998259), and LARGE (rs240070) were associated with treatment response defined as at least 30% pain reduction (α≤0.05). An intergenic interaction was observed in GCH1 (rs998259/rs3783641). A multivariate model which included the GCH1 polymorphisms was able to account for ~76% of variability in response to OMT. This study successfully demonstrated an association between genetics and response to OMT.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29021
dc.language.isoen
dc.provenance.legacyDownloads35
dc.subjectGenetics
dc.subjectGenetics and Genomics
dc.subjectMedical Genetics
dc.subjectOsteopathic Medicine and Osteopathy
dc.subjectChronic Lower Back Pain
dc.subjectOsteopathic Manipulative Treatment
dc.subjectGenetics
dc.titleDetermination of Genetic Factors Associated with Response to Osteopathic Manipulative Treatment (OMT) in Individuals with Chronic Lower Back Pain (CLBP).
dc.typeThesis
dc.type.materialtext
thesis.degree.disciplineForensic Genetics
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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