DSpace at UNTHSC: Recent submissions
Now showing items 21-40 of 4975
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NorTex Spring 2022 Newsletter
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Investigating the role of interleukin 1 alpha during Listeria monocytogenes infection
(2022-05)Listeria monocytogenes (LM) causes listeriosis, one of the leading causes of death by foodborne illness in the United States. Although generally self-limiting in immunocompetent people, listeriosis can cause meningitis or ... -
Assessment of Sex Differences Following Repeated Mild Head Injuries
(2022-05)There is limited information about sex differences in mRHI, despite some studies suggesting females participating in contact sports experience more head injuries than males. This study will test the hypothesis that mRHI ... -
Testosterone Replacement Therapy: Role in Modulating Oxidative Stress within the Entorhinal Cortex
(2021-05)Sleep apnea affects approximately a quarter of all Americans. The effects of sleep apnea involve a decrease in testosterone levels, along with an increased rate of hypertension, stroke, and coronary heart disease. Chronic ... -
The Effect of Tooth Loss on Craniofacial Morphology
(2021-05)Tooth loss (edentulism) is known to reduce biomechanical loading of the face, resulting in changes in craniofacial morphology and bone material properties. However, the effect of tooth loss on masticatory muscles and their ... -
Protein Biomakers of Estrogenic Impact on Mouse and Rat Uterus
(2021-05)Understanding the structural and morphological impact that occur in the uterus upon exposure to estrogens can reveal how these hormones elicit changes in the organ. This study seeks to revalidate the data obtained in studies ... -
The role of aging and length of hypogonadism on the neuroprotective effects of dietary genistein following focal cerebral ischemia
(2021-05)The risk of ischemic stroke increases with increasing age. Women beyond menopause have an exponential increase in stroke risk with worse post-stroke prognosis and mortalities compared to men of similar ages. One of the key ... -
Effects of a Synthetic Amino Acid Diet: Insights from the Guy Microbiome, Inflammation, and Behavior
(2021-05)Phenylketonuria (PKU) is an inborn error of phenylalanine metabolism primarily treated through a phenylalanine-restrictive diet and frequently supplemented with an amino acid formula to maintain proper nutrition. PKU ... -
miRNA Profiling of Human Optic Nerve Head Astrocytes Exposed to Cyclic Stretch
(2021-05)Glaucoma is a leading cause of irreversible blindness. Vision loss results from the degeneration and death of retinal ganglion cells (RGCs) and their axons. The primary risk factor for glaucoma is increased intraocular ... -
Investigating the Effect of 17β-Estradiol on 24(S)-hydroxycholesterol Concentration in Brain Tissue
(2021-05)Estrogen, more specifically 17β-estradiol (E2), has been found to have neuroprotective effects in the brain. With Alzheimer's patients being comprised mainly of women, it is worthwhile to investigate the role that reproductive ... -
Investigating the Use of Resistance Breathing for the Detection of Acute Hypovolemia
(2021-05)Introduction: Standard vital signs (e.g., heart rate and blood pressure) lack sensitivity and specificity to detect blood volume status following hemorrhage. Inspiratory resistance breathing has therapeutic potential to ... -
Prenatal Hypoxic Insults Impact Brain Vulnerability
(2021-05)Maternal hypoxic insults during gestation may lead to an increased risk for neurodegenerative diseases, such as Parkinson's disease (PD), in progeny. Maternal hypoxic stress is a common consequence of many late-stage ... -
Effects of Osteopathic Manipulative Treatment on Parkinsonian Gait: A Statistical Parametric Mapping Analysis
(2021-05)Introduction/Background: Tens of thousands of people are diagnosed with Parkinson's disease (PD) each year, making it the second most common neurodegenerative disorder. PD results in a variety of gait disturbances that ... -
Slow Recovery of Cerebral Perfusion During Hypotension in Elderly Humans
(2021-05)Purpose: The study sought to test the hypothesis that the function of maintaining cerebral perfusion is diminished in elderly adults due to compromised cerebral autoregulation (CA) and cardiovascular systemic mechanisms ... -
Examination of Ventilation Before and After Advanced Airway Placement During Continuous Chest Compressions Cardiopulmonary Resuscitation
(2020-05)Purpose: The aim of this project was to identify a method to measure ventilation during continuous chest compressions CPR that will improve outcomes for resuscitation attempts on out of hospital cardiac arrest patients ... -
Modulation of Astrocyte Phenotype in Response to T-cell Interaction
(2021-05)We determined that T-cell astrocyte interaction modulates interleukin-10 (IL-10) production from both cell types. The impact of IL-10 on astrocytes was compared to IL-10 generated from T-cell-astrocyte interactions in ... -
Retrospective Analysis of Phase 4 Clinical Trial to Evaluate the Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension
(2021-05)One of the biggest challenges patients with rare diseases face is the availability of safe and effective treatment options. Patients with symptomatic neurogenic orthostatic hypotension have a very limited number of ... -
Effects of antioxidants on nicotine recognition in rats
(2020-05)According to the CDC, nicotine addiction accounts for over 7 million deaths a year worldwide, twice that of narcotics and alcohol combined (11). Most adults need 30 attempts to quit smoking for a year or longer, and this ... -
Characterization of Markers on Pancreatic and Colon Cancer Stem Cells to Enhance Natural Killer Cell Effector Functions
(2021-05)Due to advancements in technology and medicine, the average human lifespan in the United States has increased to 79 years since the start of the 20th century. This increase in lifespan is also coupled with an increased ... -
Association of Pain Sensitivity with Outcome Measures for Quality of Life, Functional Ability and Current Pain Intensity in Chronic Low Back Pain
(2021-05)Pain sensitivity, as measured by the self-reported Pain Sensitivity Questionnaire (PSQ), was investigated using data from the PRECISION Pain Research Registry. Outcome measures for quality of life, functional ability, and ...