Attribution 4.0 International (CC BY 4.0)2022-09-092022-09-092020-05-09Chakrabarti, S. S., Kaur, U., Banerjee, A., Ganguly, U., Banerjee, T., Saha, S., Parashar, G., Prasad, S., Chakrabarti, S., Mittal, A., Agrawal, B. K., Rawal, R. K., Zhao, R. C., Gambhir, I. S., Khanna, R., Shetty, A. K., Jin, K., & Chakrabarti, S. (2020). COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity?. Aging and disease, 11(3), 480-488. https://doi.org/10.14336/AD.2020.04022152-5250https://hdl.handle.net/20.500.12503/31690The ongoing Corona virus (COVID-19) pandemic has witnessed global political responses of unimaginable proportions. Many nations have implemented lockdowns that involve mandating citizens not to leave their residences for non-essential work. The Indian government has taken appropriate and commendable steps to curtail the community spread of COVID-19. While this may be extremely beneficial, this perspective discusses the other reasons why COVID-19 may have a lesser impact on India. We analyze the current pattern of SARS-CoV-2 transmission, testing, and mortality in India with an emphasis on the importance of mortality as a marker of the clinical relevance of COVID-19 disease. We also analyze the environmental and biological factors which may lessen the impact of COVID-19 in India. The importance of cross-immunity, innate immune responses, ACE polymorphism, and viral genetic mutations are discussed.http://creativecommons.org/licenses/by/4.0/Ace2Covid-19Indiacross-immunitymortalitytransmissionArticle© 2020 Chakrabarti S et al.113