Attribution 4.0 International (CC BY 4.0)2022-09-092022-09-092017-10-01Xu, X., Wang, B., Ren, C., Hu, J., Greenberg, D. A., Chen, T., Xie, L., & Jin, K. (2017). Age-related Impairment of Vascular Structure and Functions. Aging and disease, 8(5), 590-610. https://doi.org/10.14336/AD.2017.04302152-5250https://hdl.handle.net/20.500.12503/31685Among age-related diseases, cardiovascular and cerebrovascular diseases are major causes of death. Vascular dysfunction is a key characteristic of these diseases wherein age is an independent and essential risk factor. The present work will review morphological alterations of aging vessels in-depth, which includes the discussion of age-related microvessel loss and changes to vasculature involving the capillary basement membrane, intima, media, and adventitia as well as the accompanying vascular dysfunctions arising from these alterations.http://creativecommons.org/licenses/by/4.0/arterial stiffnessendothelial dysfunctionvascular agingvascular remodelingArticle© 2017 Xu X, et al.85