2024-04-162024-04-162024-03-21https://hdl.handle.net/20.500.12503/32585Two outpatient adult cases of primary leiomyosarcomas are reported in atypical locations. As a tumor of smooth muscle origin, leiomyosarcomas are most frequently found in the uterus, intestines, and other parts of the digestive tract (Rizwan et al., 2020). Here, we highlight and discuss two separate relatively nonaggressive appearing cases of leiomyosarcoma in the wrist and the thigh, encasing a superficial wrist vein and the greater saphenous vein respectively. The leiomyosarcoma of the right wrist was found in a 65-year-old male who presented with a non-painful ulnar sided nodule progressing in size for one year. Similarly, the leiomyosarcoma of the left thigh was discovered in a 52-year-old man who presented with a non-painful "knot" he had noticed enlarging over the course of just a few months. Review of the literature suggests less than 50 patients have been reported to have leiomyosarcoma of the great saphenous vein from 1868 to 2020 (Tresgallo-Parés et al., 2021). The number of vascular leiomyosarcomas arising in the superficial veins of the wrist are even lower with a 2006 case report from the Annals of Vascular Surgery suggesting only one previous case has arisen from the superficial vein over the dorsal wrist (Fu, T. Y et.al., 2007). The purpose of this report is to draw attention to a rare yet grave diagnosis to ensure that leiomyosarcoma is at least included in the differential diagnosis of rapidly enlarging nontender soft tissue masses of the extremities that encase veins.enposter