2019-08-222019-08-222014-032014-02-02https://hdl.handle.net/20.500.12503/26921Bariatric surgery has been effective in promoting sustained weight loss and improving diabetes control in many patients with morbid obesity. Increases in GLP-1 after bariatric surgery have been implicated in improved glucose homeostasis in studies examining Roux-en-Y gastric bypass. However similar studies in laparoscopic gastric banding surgery (LGBS) have been conflicting. The co-authors of the present study previously reported an increase in GLP-1 and a decrease in insulin 6 months after LGBS. The aim of this study was to further evaluate sustained changes in GLP-1 and insulin after LGBS. Purpose (a): The following hypotheses were examined: (1) Fasting and post-prandial (pp) GLP-1 will be increased 12 months after LGBS, and (2) Fasting and pp-insulin will be decreased after LGBS. Relationships between GLP-1 and weight loss were explored. Methods (b): Thirteen LGBS patients (9 women and 4 men) who underwent pre-surgical and 6-month post-surgical testing were retested at 12-months post-surgically. Average baseline BMI was 40.5 (32.4-48.4). Average age was 47.5 (24-66). Fasting and pp-blood samples were taken to evaluate GLP-1 and insulin. Data were analyzed using repeated measures ANOVA. Results (c): In comparison to baseline, fasting GLP-1 increased (F=6.46, p=0.006), fasting insulin decreased (F=6.11, p=0.022) and pp-insulin decreased (F=9.46, p=0.008). The ppGLP-1 increase approached significance (F=3.70, p=0.065), with a significant post-hoc pairwise finding at 12-months in comparison to baseline (p=0.004). Conclusions (d): Results suggest that LGBS improves GLP-1 and insulin as early as 6 months and that these improvements persist up to 1 year. Overall, these improvements appear independent of weight loss, although exploration of data suggests a possible connection with post-prandial GLP-1 at 12-months. These results provide further evidence of the efficacy of LGBS for the treatment of diabetes.enGLP-1InsulinLap Band Surgeryposter