Peter B. Raven2019-08-222019-08-221996-12-012014-04-02https://hdl.handle.net/20.500.12503/29097Smith, Scott A., Interaction of the exercise pressor reflex with central command in the regulation of blood pressure during dynamic exercise. Master of Science (Biomedical Sciences, Integrative Physiology), October, 1996, 73 pp., 7 tables, 8 figures, references. Ten subjects, aged 26.5±3.7 years, performed incremental workload cycling exercise to investigate the interaction of skeletal muscle mechano- and metaboreceptors in the regulation of blood pressure. Each subject performed four bouts of exercise: control (exercise with no intervention); exercise with thigh cuff inflation to 90 mmHg (to reduce venous outflow stimulating metaboreceptors); exercise with application of lower body positive pressure (LBPP) to 45 mmHg (to enhance mechanoreceptor activation); and exercise with application of lower body positive pressure (LBPP) to 45 mmHg (to enhance mechanoreceptor activation); and exercise with the application of both LBPP and thigh cuff inflation. Measurements of mean arterial pressure (MAP), heart rate (HR), electromyographic activity (EMG), rate of oxygen uptake (VO2)3 cardiac output (Q), and rating of perceived exertion for both the body (RPEB) and the legs (RPEL) were monitored. Significant mean data is presented. Indices of central command (HR, EMG, and VO2) were not significantly different between the four bouts of exercise indicating that the blood pressure response to central command activity was not altered by the interventions. Significant changes in RPEL from control during inflation of thigh cuffs, application of LBPP, and their combination indicate these stimuli successfully enhanced mechano- and metaboreceptor activation. Results indicate that MAP was significantly elevated from control only with the application of LBPP or the combination of LBPP and thigh cuff inflation. These data suggest that mechanoreceptors are the primary exercise pressor mediator of arterial blood pressure during submaximal dynamic exercise.application/pdfenCardiologyMedical SciencesMedical SpecialtiesMedicine and Health SciencesBlood PressureExerciseblood pressure regulationThesis