Singh, Meharvan2019-08-222019-08-222008-05-012014-03-31https://hdl.handle.net/20.500.12503/29478Roth, Cherice, STAT6 and its relationship with PSA and Annexin A2 in Human Prostate Cancer. Master of Science (Biochemistry and Molecular Biology), May 2008, 49 pages, 13 illustrations, reference list, 54 titles. The increase of signal transducer and activator of transcription (STAT6) has been correlated with increased prostate tumor size as well as Gleason score. This molecule’s exact role in prostate cancer is still unknown. This research focused on the relationships of STAT6 in prostate specific antigen (PSA) expression as well as its novel interaction with annexin A2. These data show that STAT6 is involved in an alternate PSA expression pathway. It is also concluded that the interaction of STAT6 and annexin A2 increased the activated STAT6 (p-STAT) but not total STAT6. Chromatin immunoprecipitation also confirmed the novel protein-protein interaction between STAT6 and annexin A2 is nuclear.application/pdfenBiochemistryCancer BiologyCell and Developmental BiologyCell BiologyCellsCellular and Molecular PhysiologyDiseasesLife SciencesMale Urogenital DiseasesMedical Cell BiologyMedical Molecular BiologyMedicine and Health SciencesMicrobiologyMolecular BiologyOncologyOther Cell and Developmental BiologyReproductive and Urinary PhysiologySTAT6relationshipPSAAnnexin A2human prostate cancersignal transducer and activator of transcriptionprostate tumor sizeGleason scoremoleculeroleexpression pathwaychromatin immunoprecipitationprotein-protein interactionThesis