Attribution 4.0 International (CC BY 4.0)2022-07-072022-07-072020-11-30Morris, J. K., John, C. S., Green, Z. D., Wilkins, H. M., Wang, X., Kamat, A., Swerdlow, R. S., Vidoni, E. D., Petersen, M. E., O'Bryant, S. E., Honea, R. A., & Burns, J. M. (2020). Characterization of the Meal-Stimulated Incretin Response and Relationship With Structural Brain Outcomes in Aging and Alzheimer's Disease. Frontiers in neuroscience, 14, 608862. https://doi.org/10.3389/fnins.2020.6088621662-4548https://hdl.handle.net/20.500.12503/31535Background: Individuals with Alzheimer's Disease (AD) are often characterized by systemic markers of insulin resistance; however, the broader effects of AD on other relevant metabolic hormones, such as incretins that affect insulin secretion and food intake, remains less clear. Methods: Here, we leveraged a physiologically relevant meal tolerance test to assess diagnostic differences in these metabolic responses in cognitively healthy older adults (CH; n = 32) and AD (n = 23) participants. All individuals also underwent a comprehensive clinical examination, cognitive evaluation, and structural magnetic resonance imaging. Results: The meal-stimulated response of glucose, insulin, and peptide tyrosine tyrosine (PYY) was significantly greater in individuals with AD as compared to CH. Voxel-based morphometry revealed negative relationships between brain volume and the meal-stimulated response of insulin, C-Peptide, and glucose-dependent insulinotropic polypeptide (GIP) in primarily parietal brain regions. Conclusion: Our findings are consistent with prior work that shows differences in metabolic regulation in AD and relationships with cognition and brain structure.http://creativecommons.org/licenses/by/4.0/Alzheimer's diseaseMRIPYYglucoseinsulininsulin resistanceneuroimagingvoxel based morphometryAlzheimer DiseaseMagnetic Resonance ImagingPeptide YYArticleCopyright © 2020 Morris, John, Green, Wilkins, Wang, Kamat, Swerdlow, Vidoni, Petersen, O'Bryant, Honea and Burns.14