Attribution-NonCommercial-NoDerivs 4.0 International2024-01-032024-01-032024-01-02Housini, M., Zhou, Z., Gutierrez, J., Rao, S., Jomaa, R., Subasinghe, K., Reid, D. M., Silzer, T., Phillips, N., O'Bryant, S., Barber, R. C., & HABS-HD Study Team (2023). Top Alzheimer's disease risk allele frequencies differ in HABS-HD Mexican- versus Non-Hispanic White Americans. Alzheimer's & dementia (Amsterdam, Netherlands), 15(4), e12518. https://doi.org/10.1002/dad2.125182352-8729https://hdl.handle.net/20.500.12503/32450INTRODUCTION: Here we evaluate frequencies of the top 10 Alzheimer's disease (AD) risk alleles for late-onset AD in Mexican American (MA) and non-Hispanic White (NHW) American participants enrolled in the Health and Aging Brain Study-Health Disparities Study cohort. METHODS: Using DNA extracted from this community-based diverse population, we calculated the genotype frequencies in each population to determine whether a significant difference is detected between the different ethnicities. DNA genotyping was performed per manufacturers' protocols. RESULTS: Allele and genotype frequencies for 9 of the 11 single nucleotide polymorphisms (two apolipoprotein E variants, CR1, BIN1, DRB1, NYAP1, PTK2B, FERMT2, and ABCA7) differed significantly between MAs and NHWs. DISCUSSION: The significant differences in frequencies of top AD risk alleles observed here across MAs and NHWs suggest that ethnicity-specific genetic risks for AD exist. Given our results, we are advancing additional projects to further elucidate ethnicity-specific differences in AD.http://creativecommons.org/licenses/by-nc-nd/4.0/Alzheimer's diseaseHispanicMexican Americandementiadiversitygeneticshealth disparitiesmild cognitive impairmentArticle© 2023 The Authors.154