Attribution 4.0 International (CC BY 4.0)2022-09-062022-09-062021-08-20Maldonado-Cabrera, A., Angulo-Molina, A., Haque, U., Velazquez, C., Álvarez-Villaseñor, A. S., Santacruz-Gómez, K. J., & Gallego-Hernández, A. L. (2021). Acute Inflammatory Mediators in Young Adult Patients with COVID-19 in Mexico. Pathogens (Basel, Switzerland), 10(8), 1056. https://doi.org/10.3390/pathogens100810562076-0817https://hdl.handle.net/20.500.12503/31668Young adults (18-40 years old) are an active population with high risk of infection and transmission of COVID-19. They are considered a low-risk population due to its low 1.0% case fatality rate (CFR). Despite their high clinical usefulness to prevent fatal cases, inflammatory and coagulation biomarkers studies are limited. For this reason, we performed a retrospective cohort study with COVID-19 patients in Hermosillo, Mexico, to assess inflammation, coagulopathy profile, and severity outcomes in young adults. We analyzed blood samples to determine the neutrophil/lymphocyte ratio (NLR), neutrophil/monocyte ratio (NMR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), and C-reactive protein (C-RP). We included epidemiological features and comorbidities, and compared them to the severity status. Only 359 COVID-19-confirmed young adults were included in the ambulatory (44.8%), hospitalized (42.9%), and death (12%) severity groups. Laboratory results showed an increase in NMR, LMR, and C-RP associated with the aggravated patients. Additionally, obesity, arterial hypertension, and type-2 diabetes mellitus (T2DM) were associated with the COVID-19 severity outcome. We found that 9.1% and 30.3% of young adults presented the novel COVID-19-associated coagulopathy (CAC) and the risk of CAC, respectively. These parameters can be considered independent biomarkers reflecting an enhanced inflammatory process related to the COVID-19 prognosis.http://creativecommons.org/licenses/by/4.0/Covid-19coagulopathyhematological profilesyoung adultsArticle© 2021 by the authors.108