Simecka, Jerry W.2019-12-022019-12-022018-12https://hdl.handle.net/20.500.12503/29757Animal models are useful tools in the study and development of clinical solutions to pathogens. Our focus is on two clinically relevant bacterium: Mycoplama pnumoniae which can lead to community acquired pneumonia and Staphylococcus aureus which can result in osteomyelitis. We formed experimental designs to establish murine models for these pathogens. By testing multiple strains of mycoplasma within mice, infecting both immunocompetent and immunodeficient mice as well as humanized mice, we have begun the preliminary development of a humanized mouse model for M. pneumoniae. As well, by testing multiple strains of S. aureus and their ability to both attach to and from biofilm on orthopedic pins, we've developed the first steps toward a murine model for S. aureus Osteomyelitis.application/pdfenmouse modelosteomyelitispneumoniaStapylococcus aureusMycoplasma pneumoniae/pathogenicityMurine pneumonia virus/pathogenicityDisease Models, AnimalOsteomyelitisStaphylococcus aureus/pathogenicityThesis