Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)2022-09-092022-09-092021-02-26Jiang, H., Xiao, L., Jin, K., & Shao, B. (2021). Estrogen administration attenuates post-stroke depression by enhancing CREB/BDNF/TrkB signaling in the rat hippocampus. Experimental and therapeutic medicine, 21(5), 433. https://doi.org/10.3892/etm.2021.98501792-0981https://hdl.handle.net/20.500.12503/31694A previous study demonstrated that 17beta-estradiol (E2), which is an antidepressant, can ameliorate post-stroke depression (PSD); however, the underlying mechanisms governing this remain largely unknown. Therefore, the present study developed a PSD model in rats, which was induced by left middle cerebral artery occlusion followed by exposure to chronic mild stress for 2 weeks. The results revealed that the activity of the cAMP response element-binding protein (CREB), a cellular transcription factor, and the associated brain-derived neurotrophic factor (BDNF)/tyrosine kinase B (TrkB) signaling were all attenuated in the hippocampus in PSD rats. The depression-like behaviors were significantly improved after treatment with E2, along with increased CREB and the BDNF/TrkB signaling activity. These results provide novel insight into the molecular basis of PSD, and suggest the potential involvement of CREB/BDNF/TrkB signaling in E2-mediated improvement of PSD in rats.http://creativecommons.org/licenses/by-nc-nd/4.0/brain-derived neurotrophic factorcAMP response element-binding proteindepressionestrogenhippocampusstroketyrosine kinase BArticle© Jiang et al.215