Pharmaceutical Sciences
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12503/30449
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Browsing Pharmaceutical Sciences by Author "Dong, Xiaowei"
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Item Sorafenib loaded In-situ Self-Assembling Nanoparticle: A novel approach to increasing oral bioavailability(2021) Mans, Jaylen C.; Dong, XiaoweiPurpose: Sorafenib (SFN), a multi-kinase inhibitor, has demonstrated potent anticancer activity. However, the efficacy of orally administered SFN is limited due to its poor water solubility, leading to low absorption and bioavailability. The novel nanotechnology, In-situ Self-assembling Nanoparticles (ISNP), has shown potential to overcome low solubility in complex drug candidates. The objective of this study was to investigate ISNP nanotechnology as an approach to overcome low solubility and bioavailability of orally administered SFN. Method: SFN-ISNP granules were prepared using D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), Miglycol-12, Aeroperl-300, and SFN powder. SFN-ISNPs were characterized by particle size, drug loading (DL), entrapment efficiency (EE%) and physical structure using DLS, HPLC, and DSC analytical methods. SFN-ISNP granules were orally administered to rats, and the SFN concentrations in blood plasma and tissues were measured using LC-MS. Results: In-vitro characterization of SFN-ISNPs resulted in particle size of 181 ± 24 nm, PDI< 0.28, DL of 8.825% ± 0.36% and EE% of >99.9%(n=4). DSC analysis indicated SFN was present in an amorphous physical state within the granule. The pharmacokinetic study results demonstrate that the ISNP nanotechnology significantly increased bioavailability. Peak plasma concentration of SFN-ISNP granules resulted in 4.5-fold increase compared to SFN powder. Biodistribution results indicate that SFN-ISNP granules significantly increased SFN distribution to tissue. Conclusion: The novel ISNP drug delivery technology is a promising innovation that has demonstrated an ability to increase drug absorption and bioavailability of orally administered SFN.Item Ternary Pseudo-Triphasic Phase Diagram for Lipid Formulation(2021) Dulie Kom Nzia, Jeanne; Dong, XiaoweiPurpose: Lipid-based formulations are frequently studied, they improve oral bioavailability of water-insoluble drugs and constitute 40% of new drugs. A ternary pseudo-phase diagram(TPPD) is a thesaurus tool used to define specific physical compositions of a thermodynamically stable solution. The aim of this study was to construct TPPD of lipid-based formulations and identify optimum composition for drug delivery. Method: The aqueous titration experimental method was used. A lipid and surfactant components were mixed in a fixed ratio. No cosurfactant was used. The mixture was heated at 45°C. Water was used as a titer and was added in increment of 5%-10% to up to 95% of the total mixture. After equilibrium, the mixture was observed for characterization. Data were gathered on a table, showing each increment of water, the amount of each component, and the percentage of each component in the mixture. Data collected were used to build TPPD through excel. Result: Comparing one set of 3 phase diagrams(PDs), the PD(Miglyol-812, TPGS, Water) presents a larger area of clear solution(CS), a very small area of microemulsion, and a small area of emulsion. The PD(Miglyol-812, Tween 80, Water) presents a smaller area of CS, a small area of microemulsion, and a larger area of emulsion. The PD(Miglyol-812, K El, Water) presents a small area of CS, a small area of microemulsion, and a large area of emulsion. Conclusion: All PD built present stable area of emulsion and microemulsion that can be reconstituted for optimum delivery.