Kunlin Jin, Ph.D.
Permanent URI for this communityhttps://hdl.handle.net/20.500.12503/21594
Professor, Pharmacology & Neuroscience
Member, Institute for Healthy Aging
Email: Kunlin.Jin@unthsc.edu
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Browsing Kunlin Jin, Ph.D. by Author "Bao, Han"
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Item NeuroD4 converts glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 antioxidant axis(Springer Nature, 2023-08-16) Wang, Hao; Zhao, Peiqi; Zhang, Ying; Chen, Zhen; Bao, Han; Qian, Wenqi; Wu, Jian; Xing, Zhenqiu; Hu, Xiaowei; Jin, Kunlin; Zhuge, Qichuan; Yang, JianjingCell fate and proliferation ability can be transformed through reprogramming technology. Reprogramming glioblastoma cells into neuron-like cells holds great promise for glioblastoma treatment, as it induces their terminal differentiation. NeuroD4 (Neuronal Differentiation 4) is a crucial transcription factor in neuronal development and has the potential to convert astrocytes into functional neurons. In this study, we exclusively employed NeuroD4 to reprogram glioblastoma cells into neuron-like cells. In vivo, the reprogrammed glioblastoma cells demonstrated terminal differentiation, inhibited proliferation, and exited the cell cycle. Additionally, NeuroD4 virus-infected xenografts exhibited smaller sizes compared to the GFP group, and tumor-bearing mice in the GFP+NeuroD4 group experienced prolonged survival. Mechanistically, NeuroD4 overexpression significantly reduced the expression of SLC7A11 and Glutathione peroxidase 4 (GPX4). The ferroptosis inhibitor ferrostatin-1 effectively blocked the NeuroD4-mediated process of neuron reprogramming in glioblastoma. To summarize, our study demonstrates that NeuroD4 overexpression can reprogram glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 signaling pathway, thus offering a potential novel therapeutic approach for glioblastoma.