Fan Zhang, Ph.D.
Permanent URI for this communityhttps://hdl.handle.net/20.500.12503/31204
Associate Professor, Family Medicine and Osteopathic Manipulative Medicine
Email: Fan.Zhang@unthsc.edu
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Browsing Fan Zhang, Ph.D. by Author "Ances, Beau M."
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Item Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study(Wiley Periodicals, Inc., 2020-06-30) Petersen, Melissa E.; Zhang, Fan; Schupf, Nicole; Krinsky-McHale, Sharon J.; Hall, James R.; Mapstone, Mark; Cheema, Amrita; Silverman, Wayne; Lott, Ira; Rafii, Michael S.; Handen, Benjamin; Klunk, William; Head, Elizabeth; Christian, Bradley; Foroud, Tatiana; Lai, Florence; Rosas, H. Diana; Zaman, Shahid; Ances, Beau M.; Wang, Mei-Cheng; Tycko, Benjamin; Lee, Joseph H.; O'Bryant, Sid E.Introduction: Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) and Alzheimer's disease (DS-AD) from those cognitively stable (CS). Methods: Data were analyzed on n = 305 (n = 225 CS; n = 44 MCI-DS; n = 36 DS-AD) enrolled in the Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS). Results: Distinguishing MCI-DS from CS, the serum profile produced an area under the curve (AUC) = 0.95 (sensitivity [SN] = 0.91; specificity [SP] = 0.99) and an AUC = 0.98 (SN = 0.96; SP = 0.97) for plasma when using an optimized cut-off score. Distinguishing DS-AD from CS, the serum profile produced an AUC = 0.93 (SN = 0.81; SP = 0.99) and an AUC = 0.95 (SN = 0.86; SP = 1.0) for plasma when using an optimized cut-off score. AUC remained unchanged to slightly improved when age and sex were included. Eotaxin3, interleukin (IL)-10, C-reactive protein, IL-18, serum amyloid A , and FABP3 correlated fractions at r2 > = 0.90. Discussion: Proteomic profiles showed excellent detection accuracy for MCI-DS and DS-AD.