Browsing by Author "Eke, Ikechukwu"
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Item Association of Sedentary Behavior with Salivary Estradiol Level Among African-american Women Who Are Overweight(2017-03-14) Kitzman-Ulrich, Heather; Dodgen, Leilani; Mandapati, Surendra; Gant, Kisa; Eke, Ikechukwu; Mamun, Md AbdullahPurpose: Recent studies have reported that sedentary behavior may have multiple adverse health outcomes in adults, and is related to elevated levels of estradiol that are associated with breast cancer, ovarian cancer, and endometrial cancer. A growing body of research has assessed the association of sedentary behavior with estradiol levels, however, few studies have been in African-American (AA) overweight women who are disproportionally diagnosed with cancer. The objective of this study was to assess the association of self-reported sedentary behavior of AA overweight women with salivary estradiol level. Methods: We recruited 263 AA overweight (BMI [greater than] 25, mean BMI 36.8 (SD 8.5), mean age 49.4 (SD 11.6) years) women from a faith-based weight reduction program from 2014-2016 in Dallas, Texas. Approximately 4mL of saliva was collected over four consecutive weeks. Saliva was stored in a sub 800C freezer and sent to a lab to assay. Weekly sedentary behavior was collected with a valid and reliable survey for weekdays and weekends that included hours of sitting to watch television, working on the computer, riding in a car, bus, or train, and other sitting practices. We used Pearson’s-correlation and linear models to estimate the unadjusted and adjusted association of sedentary behavior with estradiol level. Results: Average weekly sedentary time was 40.6 hours (SD = 17.5). The range of estradiol level was 0.50 pg/mL to 3.50 pg/mL with mean 1.13 pg/mL (SD = 0.55). Sedentary time was positively associated with estradiol level (correlation coefficient = 0.18, p2= 8.4%, p Conclusions: Self-reported sedentary hours for AA overweight women were less than the national average (5.8 hours in this study vs. 7.7 hours nationally, per day). We found that sedentary time was a predictive factor for estradiol level, and higher sedentary time was associated with elevated estradiol levels. Future research should further explore how sedentary behavior and elevated estradiol levels influence cancer risk in AA women.Item Effect of Body Mass Index and Menopausal Status on Lipid Levels in African American Women(2016-03-23) Mecwan, Neil; Dodgen, Leilani; Eke, Ikechukwu; Mandapati, Surendra; Kitzman-Ulrich, Heather; Killion, JordanBackground: Lipid levels are negatively impacted by menopause. Total cholesterol (TC), low density lipoproteins (LDL), and triglyceride levels have been shown to increase due to menopause, increasing risk of cardiovascular disease (CVD). Limited research indicates this relationship may be independent of weight status. This study aims to examine lipid levels (TC, LDL-C, fasting glucose) by menopausal and weight status (Body Mass Index [BMI] [greater than] 25) in African American (AA) women to better understand this relationship. Methods: Lipid profile, BMI, and menopausal status were obtained from AA women enrolled in a NIH-funded study, Better Me Within, to evaluate a faith-based diabetes prevention program. This study included overweight and obese AA women with an absence of hysterectomy. Lipid profile (TC, LDL-C, fasting glucose) was obtained after a 12-hour fast via finger stick (Alere Cholestech LDX Analyzer). BMI was calculated with objectively collected height and weight data, and menopausal status through self-report. Results: 56 AA female participants with a mean age of 46.7 (SD=12.4) years were included. LDL, TC, and fasting glucose were all significantly higher in postmenopausal as compared to premenopausal women (all p values Conclusion: In this study of AA women, TC, LDL, and fasting glucose were higher for postmenopausal women compared to premenopausal, and in obese postmenopausal women compared to obese premenopausal women. This study indicates greater levels of BMI worsen the effect of menopausal status on lipid levels. Future research is needed to evaluate the relationship between excess weight, menopause, and lipid levels in larger samples, particularly since AA women are at higher risk for chronic conditions including diabetes and CVD.Item The Association of Body Mass Index, Body Image, and Body Satisfaction among African American Women(2016-03-23) Eke, Ikechukwu; Holmes, Esther J.; Kitzman-Ulrich, Heather; Dodgen, Leilani; Martinez Barrera, DanielAbstract The Association of Body Mass Index, Body Image, and Body Satisfaction among African American Women Purpose Obesity is a significant health issue in the United States, especially among African American (AA) women, and is associated with chronic diseases such as hyperlipidemia, hypertension, and diabetes. Barriers to weight loss among AA women may include having a more positive body image and body satisfaction. The purpose of this study was to determine if Body Mass Index (BMI) and waist circumference (WC) predict body perception and body image scores among AA women in the Better Me Within study, a randomized controlled trial evaluating a faith-enhanced diabetes prevention. Methods Baseline data were collected from 150 AA women (Means: Age = 48.5 ±11.7 years, BMI = 37.9±9.0, WC 42.7±5.9) to evaluate if the independent variables, BMI(kg/m2) and WC(cm), predict outcome variables including the Body Appreciation Scale score and the Pulver Figure Rating Scale (body discrepancy) score. Body discrepancy scores were determined by subtracting the scored ideal body shape from the scored current body shape. Linear regression controlling for education and age was used to evaluate the relationships. Results Greater WC predicted an increase in body appreciation (p0001), and a decrease in body discrepancy scores indicating more acceptance of current body size (ppp Conclusion Positive body image and perception among AA women with high BMI and WC may reduce motivation to participate in weight loss and dietary programs. Future research should evaluate other motivations to improve health in these high risk women.