Browsing by Subject "Clinical research management"
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Item Clinical Internship with the Division of Gynecologic Oncology at UT Southwestern Medical Center: Carboplatin and Doxil for Gynecologic Cancers(2003-12-01) Epps, Camitria N.; Victoria Rudick; David S. Miller; Barbara RichardsonEpps, Camitria N., Master of Science, Clinical Research Management, December 2003, Carboplatin and Doxil for Gynecologic Cancers, 107 Pages, 9 Tables, 42 titles in Bibliography. Objective: To examine the safety and efficacy of administering the drugs carboplatin and doxil in combination chemotherapy for the treatment of gynecologic cancers, mainly endometrial and ovarian cancer. Materials and Methods: Carboplatin and doxil were previously administered intravenously to 6 patients. Each patient received 3 to 8 cycles of chemotherapy. Doses of carboplatin ranged from 310 mg to 665 mg. The doses of doxil ranged from 54 mg to 80 mg. This is a retrospective study. The 6 patient’s medical charts were reviewed. Data was extracted and a spreadsheet formatted database was created. Results: Data were extracted and a spreadsheet formatted database was created. Results: Due to the small number of patients the results are not statistically significant. 2 patients showed tumor progression while receiving treatment. All patients tolerated doses very well and experienced minimal toxicities. Conclusion: Carboplatin plus doxil combination chemotherapy given intravenously has a potent effect on endometrial and ovarian cancers. Studies using this chemotherapy for the treatment of gynecologic cancers should be conducted on a wider scale to access the statistical significance of the treatment.Item Medicare 2005 Demonstration Project: Patient Reporting of Nausea Symptoms and Its Impact on Improving Quality of Patient Care(2006-01-01) Mueller, Brett H.; Rustin Reeves; Ray Page; Walter McConathyFor the completion of the requirements for my Masters degree in clinical research management, I interned under the mentorship of Ray Page, D.O., Ph.D., at the Center for Cancer and Blood Disorders. While at this site, I worked on completing my retrospective chart review research project while also gaining clinical exposure in medical and radiation oncology, observing different aspects of running and managing a medical practice, and learning how to run and manage clinical trials as a future principal investigator. The focus of my internship practicum was to analyze the effectiveness of the 2005 Oncology Demonstration Project. One-hundred thirty three patient charts were identified for this study because as some point during the 2005 year, the patient reported serious symptoms of nausea and vomiting. Over 5,000 patient notes that were documented during the 2005 year were reviewed for the one-hundred and thirty three patient population. Substantial data was collected regarding the ability of the clinicians’ and nurses’ effectiveness in administering nausea and vomiting care with, and without, the 2005 Oncology Demonstration Project. Additional activities during this internship includes shadowing DR. Page, shadowing and learning from the clinical coordinators at the Center, assisting the clinical manager with regulatory binder filling, protocol review, creating a study budget, and participating in, and helping in many other facets of clinical research carried out at the Center for Cancer and Blood Disorders.