Browsing by Subject "Exercise Therapy / methods"
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Item Establishing Equivalent Aerobic Exercise Parameters Between Early-Stage Parkinson's Disease and Pink1 Knockout Rats(IOS Press, 2022-06-28) Salvatore, Michael F.; Soto, Isabel; Kasanga, Ella A.; James, Rachael; Shifflet, Marla K.; Doshier, Kirby; Little, Joel T.; John, Joshia; Alphonso, Helene M.; Cunningham, J. Thomas; Nejtek, Vicki A.BACKGROUND: Rodent Parkinson's disease (PD) models are valuable to interrogate neurobiological mechanisms of exercise that mitigate motor impairment. Translating these mechanisms to human PD must account for physical capabilities of the patient. OBJECTIVE: To establish cardiovascular parameters as a common metric for cross-species translation of aerobic exercise impact. METHOD: We evaluated aerobic exercise impact on heart rate (HR) in 21 early-stage PD subjects (Hoehn Yahr /=3 months, >/=3x/week. In 4-month-old Pink1 knockout (KO) rats exercising in a progressively-increased treadmill speed regimen, we determined a specific treadmill speed that increased HR to an extent similar in human subjects. RESULTS: After completing aerobic exercise for approximately 30 min, PD subjects had increased HR approximately 35% above baseline ( approximately 63% maximum HR). Motor and cognitive test results indicated the exercising subjects completed the timed up and go (TUG) and trail-making test (TMT-A) in significantly less time versus exercise-naive PD subjects. In KO and age-matched wild-type (WT) rats, treadmill speeds of 8-10 m/min increased HR up to 25% above baseline ( approximately 67% maximum HR), with no further increases up to 16 m/min. Exercised KO, but not WT, rats showed increased locomotor activity compared to an age-matched exercise-naive cohort at 5 months old. CONCLUSION: These proof-of-concept results indicate HR is a cross-species translation parameter to evaluate aerobic exercise impact on specific motor or cognitive functions in human subjects and rat PD models. Moreover, a moderate intensity exercise regimen is within the physical abilities of early-stage PD patients and is therefore applicable for interrogating neurobiological mechanisms in rat PD models.Item Intensity of Usual Care Therapeutic Interventions in Inpatient Rehabilitation - A Pilot Study(2019-12) Di Pasquale, Jake A.; Millar, J. Cameron; Ranjan, Amalendu P.Minimal evidence exists describing key dosing parameters of interventions used during the subacute phase of recovery after neurological injury. This prospective cohort study aims to assess cardiorespiratory strain resulting from novel and conventional therapeutic interventions. Gait training provided relatively more moderate to vigorous exercise, reaching the associated %HRR 25% and 42% of the time in patients post spinal cord injury (SCI) and stroke, respectively. Specifically, EksoGT overground robotic gait training appears more effective, evoking targeted %HRR for 48% and 52% of sessions. Rate of Perceived Exertion (RPE) was moderately correlated with very light intensity in patients with SCI but ultimately ineffective at gauging %HRR. EksoGT can administer moderate to vigorous intensity exercise to patients with severe disabilities. Inpatient rehabilitation is inherently variable in method and population but can provide minimally sufficient exercise intensity. Further research into the dose-response relationship and accurate estimation of intensity are needed.