Browsing by Subject "Hyperlipidemia"
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Item PEDIATRICIAN CARDIOVASCULAR SCREENING RESEARCH(2013-04-12) Mou, MargaretPurpose: The objective of this project is to understand general pediatricians' screening and treatment processes in children with a variety of cardiovascular disease risk factors. We believe that less than 50% of general pediatricians follow current national guidelines for screening cholesterol in children ages 9-11. Methods: Pediatricians in the Cook Children's network were given a questionnaire via email from the Medical Staff, where the data was collected electronically. Results: 1. 29% of respondents gave cholesterol screenings 100% of the time in 9-11 year old children in routine check-ups 2. 21% of respondents gave cholesterol screenings 0% of the time in 9-11 year old children in routine check-ups 3. More respondents were likely to have a child's cholesterol screened if they had other conditions, such as Diabetes Mellitus, are obese, and have a family history of cardiovascular disease Conclusions: The sample size of this project was too small to make conclusive results, but it gives an idea of where general pediatricians come from and the mentality behind universal screening for cardiovascular health in children ages 9-11 years old.Item The Effects of Hyperlipidemia and Hypoglycemia on Myocardial Contractile Function and Oxygen Utilization During Coronary Hypoperfusion(1998-08-01) Hart, Bradley Joe; Downey, H. Fred; Mallet, Robert T.; Smith, Michael B.Hart, Bradley Joe, The Effects of Hyperlipidemia and Hypoglycemia on Myocardial Contractile Function and Oxygen Utilization During Coronary Hypoperfusion Master of Science (Biomedical Sciences), August, 1998, 85 pp., 1 table, 5 figures, references, 51 titles. This study was designed to determine the effects of elevated fatty acid and lowered glucose concentrations on myocardial contractile function and substrate selection during hypoperfusion. Coronary perfusion pressure (CPP) was lowered in the left anterior descending coronary artery of open-chest anesthetized dogs. Glucose uptake, fatty acid uptake, and percent segment shortening (%SS) were determined with normal arterial FFA concentrations (Group 1) or with elevated concentrations (Groups 2 and 3). When glucose was removed by dialysis in Group 3, FFA uptake increased and glucose uptake decreased relative to Group 1 at 40 mmHg CPP (p [less than] 0.05). Oxygen consumption significantly increased (p [less than] 0.05); however, %SS was unchanged. Thus, although the myocardium switches from fatty acid to glucose metabolism to increase oxygen utilization efficiency during hypoperfusion, blocking this switch does not contribute to a further decrease in myocardial contractile function.