Browsing by Subject "Molecular Targeted Therapy"
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Item Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes(-)4(MDPI, 2018-12-31) Mangoni, Arduino A.; Guillou, Catherine; Vanden Eynde, Jean Jacques; Hulme, Christopher; Jampilek, Josef; Li, Wei; Prokai-Tatrai, Katalin; Rautio, Jarkko; Collina, Simona; Tuccinardi, Tiziano; Sousa, Maria Emilia; Sabatier, Jean-Marc; Galdiero, Stefania; Karaman, Rafik; Kokotos, George; Torri, Giangiacomo; Luque, F. Javier; Vasconcelos, M. Helena; Hadjipavlou-Litina, Dimitra; Siciliano, Carlo; Gutschow, Michael; Ragno, Rino; Gomes, Paula A. C.; Agrofoglio, Luigi A.; Munoz-Torrero, DiegoBreakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials, which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules. [...].Item Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7(MDPI, 2020-06-28) Gutschow, Michael; Eynde, Jean Jacques Vanden; Jampilek, Josef; Kang, CongBao; Mangoni, Arduino A.; Fossa, Paola; Karaman, Rafik; Trabocchi, Andrea; Scott, Peter J. H.; Reynisson, Johannes; Rapposelli, Simona; Galdiero, Stefania; Winum, Jean-Yves; Brullo, Chiara; Prokai-Tatrai, Katalin; Sharma, Arun K.; Schapira, Matthieu; Azuma, Yasu-Taka; Cerchia, Laura; Spetea, Mariana; Torri, Giangiacomo; Collina, Simona; Geronikaki, Athina; Garcia-Sosa, Alfonso T.; Vasconcelos, M. Helena; Sousa, Maria Emilia; Kosalec, Ivan; Tuccinardi, Tiziano; Duarte, Iola F.; Salvador, Jorge A. R.; Bertinaria, Massimo; Pellecchia, Maurizio; Amato, Jussara; Rastelli, Giulio; Gomes, Paula A. C.; Guedes, Rita C.; Sabatier, Jean-Marc; Estevez-Braun, Ana; Pagano, Bruno; Mangani, Stefano; Ragno, Rino; Kokotos, George; Brindisi, Margherita; Gonzalez, Florenci V.; Borges, Fernanda; Miloso, Mariarosaria; Rautio, Jarkko; Munoz-Torrero, DiegoBreakthroughs in Medicinal Chemistry [...].Item Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging(MDPI, 2021-03-16) Yu, Mengdi; Zhang, Hongxia; Wang, Brian; Zhang, Yinuo; Zheng, Xiaoying; Shao, Bei; Zhuge, Qichuan; Jin, KunlinAging is a fundamental biological process accompanied by a general decline in tissue function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive impairment or dementia, will become a growing public health issue. Aging is also a great risk factor for many age-related diseases. Nowadays, people want not only to live longer but also healthier. Therefore, there is a critical need in understanding the underlying cellular and molecular mechanisms regulating aging that will allow us to modify the aging process for healthy aging and alleviate age-related disease. Here, we reviewed the recent breakthroughs in the mechanistic understanding of biological aging, focusing on the adenosine monophosphate-activated kinase (AMPK), Sirtuin 1 (SIRT1) and mammalian target of rapamycin (mTOR) pathways, which are currently considered critical for aging. We also discussed how these proteins and pathways may potentially interact with each other to regulate aging. We further described how the knowledge of these pathways may lead to new interventions for antiaging and against age-related disease.