Browsing by Subject "Renal Insufficiency, Chronic"
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Item Predictors of Chronic Kidney Disease During Childhood in Neonates with Bronchopulmonary Dysplasia(2022-08) Wallace, Samantha W.; Mathew, Stephen O.; Ortega, Sterling; Fudala, Rafal; Starr, MichellePremature infants are more likely to survive at earlier gestational ages today than ever before. However, many of these infants face long-term complications associated with their prematurity, as their organs have not had sufficient time to develop. This is particularly notable in the kidney and the lung. Due to physiological similarities, injury of one of these systems can lead to the injury of another, a phenomenon known as kidneylung crosstalk. Furthermore, infants who experience acute kidney injury are also at increased risk of experiencing chronic kidney disease in the future. Therefore, early identification and management of kidney and lung injuries is key for effective prevention of future chronic disease. This study addresses the frequency of kidney disease in a population of neonates with bronchopulmonary dysplasia, a chronic lung disease which is common in premature neonates.Item Retrospective analysis of phase 3 clinical trial to evaluate the efficacy of drug B in anemia secondary to chronic kidney disease(2019-12) Pollard, Kellyn; Mathew, Stephen O.; Basha, RiyazTo evaluate the hemoglobin (Hb) levels in 18 patients with anemia secondary to chronic kidney disease, the safety and efficacy of Drug B (HIF-PH inhibitor) was compared to the standard of care. The purpose was to assess whether Drug B improved baseline Hb levels after 52 weeks and evaluate adverse events (AEs) and total supplementation. Retrospective analysis of Hb values and supplemental treatments were analyzed to determine the efficacy of Drug B and AEs were assessed to determine safety. Overall, Drug B was effective at increasing Hb levels and had less AEs but required more supplementation. The efficacy of Drug B as it relates to pharmacokinetics still needs to be investigated.