Browsing by Subject "Sleep Quality"
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Item Examining the association between sleep modifiers and recovery time following sports-related concussion(2022-05) Kim, Chol Ho J.; Stankowska, Dorota L.Although previous researchers support the association of sleep disturbances negatively impacting recovery time from sports-related concussion (SRC), the degree of impact sleep disturbances have on recovery time from SRC is not well-defined. This study uses the presence and absence of sleep modifiers in the Concussion Clinical Profiles Screening tool to compare and quantify recovery time from SRC in a preadolescent, adolescent, and young adult sample. We examined patient records data obtained between August 2019 and December 2021 with inclusion criteria (1) injury date <30 days from initial evaluation, (2) SRC diagnosis, and (3) completion of treatment. Patients (sample median age 15.4 (14.3, 17.1)) were grouped based on the presence or absence of sleep modifier. Adjusting for other risk factors of prolonged recovery time (i.e., vestibular primary clinical profile, personal/family history of migraines, and personal history of anxiety/depression), the presence of sleep modifiers substantially increased recovery time by 1.45-fold (p<0.001).Item Oral and gut microbiome in chronic sleep restriction mice models(2020-12) Trinh, Heather; Barber, Robert C.; Allen, Michael S.; Zhang, YanReduced sleep quality is a common problem in the US, linked to increased risk for several disease conditions. Current evidence indicates an association between the gut microbiome and sleep modulation. With the ease of access to the oral cavity for examination and sampling, correlations between the gut and oral microbiome have clinical implications for developing health screening tools. Based on this relationship, this study examined whether changes in the gut microbiome of chronically sleep-restricted subjects were reflected in their oral microbiome. Mice models were placed on chronic sleep restriction for six weeks via the Modified Multiple Platform Method. Additionally, LPS injections were given to mice four hours prior to euthanasia (saline given to control group). Oral swabs and fecal samples were collected to profile the microbiomes, characterized using Miseq for sequencing the V4 region of the 16S rRNA gene. The oral samples exhibited less diverse range of phyla, favoring Proteobacteria and Firmicutes; while the gut samples exhibited more diverse range. Among the oral microbiome profile, only Firmicutes indicated a possible association to sleep restriction with marked decrease in abundance compared to the control mice's oral samples. Among the fecal microbiome phylum analysis, two samples (S13, S21) consistently clustered away from the rest were under the conditions of no sleep restriction with LPS injection. Unexpectedly, not all of the mice which received LPS injections clustered together on PCoA. Additional studies with larger sample size are necessary to further understand the complex mechanisms taking place.