Browsing by Subject "Stress, Physiological"
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Item Comparing Short-Term Radiographic Outcomes of Cementless Primary Reverse Total Shoulder Arthroplasty Implantation With and Without Augmentation by Humeral Matchstick Autograft: A Retrospective Cohort Study(2021-12) Ouseph, Alvin; Berg, Rance E.; Gwirtz, Patricia A.; Lund, Julia; Cohen, ClaudiaReverse Total Shoulder Arthroplasty (RTSA) is an arthroplasty procedure that is increasing in incidence in the United States (26). As the incidence of the procedure increases, the gross number of RTSA complications is also expected to increase. Humeral-sided complications, accounting for up to 21% of RTSA complications requiring revision surgery, are associated with progressive humeral bone loss (10, 28). This bone loss can be explained by Wolff's law, which states that bone will adapt according to the amount of stress placed upon it (6, 27). Per Wolff's law, having a large, stiff humeral construct will lead to humeral adaptations and implant-induced osteopenia, a phenomenon called stress shielding (5, 6). Studies by Raiss et al., have suggested that lowering the size of the humeral implant in relation to the humeral metaphysis of patients can lower the incidence of stress shielding (7-9). Surgeons at The Shoulder Center at Baylor University Medical Center in Dallas, Texas, inspired by Raiss et al., have developed and implemented a new matchstick autografting procedure to reduce the size of humeral implants and combat the risk of stress shielding. This study seeks to evaluate whether the recommendations and results of Raiss et al. hold true with regards to the new matchstick RTSA procedures as well as traditional RTSA procedures performed by surgeons at The Shoulder Center (9).Item The impact of early life stressors on the progression of SLE(2021-08) Hartman, Rusty L.; Mathis, Keisa W.; Cunningham, J. Thomas; Hodge, Lisa M.; Tune, Johnathan D.Our preliminary studies show that an established model of systemic lupus erythematosus (SLE), the female NZBWF1 mouse, had worsened indices of disease later in life when the mice were shipped to our institution at an early age during the summer. We hypothesized that interleukin (IL)-6-induced release of heat shock protein 90 (HSP90) is upregulated in response to this summer early-life stressor, thus accelerating autoimmunity and renal disease in female SLE mice. To begin to study this, we measured renal IL-6 and HSP90 in 6-week-old female NZBWF1 mice that were shipped in winter or summer months and found that both were elevated immediately following summer compared to winter travel. Our findings indicate that the mediators associated with early-life travel/seasonal stressors may predict the progression of autoimmunity in SLE-prone mice. Other findings here within highlight the specificity of this effect in the kidney and describe sex differences in the observed phenomena.Item The Impact of Travel Stressors on the Pathogenesis of Autoimmunity in Female Lupus Mice(2022-05) Dinh, Viet Q.; Mathis, Keisa W.; Ma, Rong; Cunningham, J. Thomas; Basha, RiyazPreliminary studies found that an established model of systemic lupus erythematosus, the female NZBWF1 mouse, developed heightened disease severity later in life when shipped to UNTHSC during summer due to travel stressors. We hypothesized that this was partly due to early life stress that the mice experienced, and that eliminating these stressors will attenuate disease severity. We measured biomarkers of disease severity in NZBWF1 mice that were shipped as adults and compared with mice that were shipped in early life along with mice that were not shipped at all. We found that long-term biomarkers were higher in adult travel mice compared to early life travel mice, that these biomarkers were higher in summer mice compared to winter mice, and that non-travelling mice had the highest levels. Our findings indicate that adulthood stress exacerbates disease progression in NZBWF1 mice, and that seasonal factors impacted lupus pathogenesis in these adult mice.