Browsing by Subject "cognitive function"
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Item Association between magnesium intake and cognition in US older adults: National Health and Nutrition Examination Survey (NHANES) 2011 to 2014(Alzheimer's Association, 2022-02-01) Tao, Meng-Hua; Liu, Jialiang; Cervantes, DianaIntroduction: Identifying nutrition- and modifiable lifestyle-based risk factors for cognitive decline and dementia may contribute future primary prevention strategies. This study aimed to evaluate the associations between magnesium intake and cognition in older adults in the United States. Methods: Based on the National Health and Nutrition Survey (NHANES) between 2011 and 2014, the study included 2508 participants aged 60 years and older. Linear regression models were used to examine the association of total magnesium intake with cognition. Results: After adjusted demographic and other confounding factors, intakes of energy and total calcium, and serum vitamin D level, higher intake of total magnesium was independently associated with 0.15 higher global cognitive z-score (95% confidence interval, 0.02 to 0.28 for highest vs. lowest quartile, P trend = .037). The positive association of total magnesium intake with global cognition was primarily presented among women, non-Hispanic Whites, and those with sufficient serum vitamin D levels (≥50 nmol/L), although interactions were not significant. There were no clear linear associations for global cognition with serum vitamin D level. Discussions: Our findings suggest that high magnesium intake alone may improve cognition in older adults, particularly among non-Hispanic Whites and subjects with sufficient levels of serum vitamin D. Further studies are needed to confirm the findings.Item EFFECTS OF METABOLIC ACIDOSIS ON MOTOR AND COGNITIVE FUNCTION IN YOUNG AND AGED MICE(2013-04-12) Kindle, RobbynPurpose: Metabolic acidosis is defined as a reduction of serum pH below 7.4 due to the inability of the kidneys to remove an adequate proportion of hydrogen protons (H+), and can be a symptom of diabetes, kidney disease, and aging. The effects of acidosis on the nervous system are not well understood, and little research has been done to establish those effects and their potential role in cognitive decline. Methods: Four- and twenty-month-old male C57BL/6J mice (n=8) were fed either a control diet or the control diet supplemented with 2% ammonium chloride (NH4Cl) to induce metabolic acidosis. Urine pH was measured weekly to insure inducement of acidosis in the NH4Cl supplemented diet groups. After 4 weeks of pre-treatment, the mice were tested for various functional tasks and remained on their respective diet during behavioral testing. The tests were done in the following order: locomotor activity, reflexes, wire suspension, bridge walking, active avoidance (T-maze), and Morris water maze. Results: Overall, urine pH of the mice on the NH4Cl diet was decreased compared to control mice. Though the NH4Cl diet did not seem to affect the weights of the young mice, a significant decrease was seen in the aged mice. Aged mice on the NH4Cl diet had increased spontaneous activity and better performance on motor tasks. On spatial learning and memory, the NH4Cl mice learned to locate the platform more efficiently than their age-matched controls. In general, the NH4Cl mice took fewer trials to reach the criteria of avoidance and discrimination. Conclusions: Interestingly, the data suggest a potential benefit on motor and cognitive function of a mild acidosis in young and aged mice. More studies will solidify these observed effects and identify a potential mechanism by investigating acid sensing ion channel concentration in various brain regions through immunoblot analysis.Item Metabolic Acidosis-Induced Alterations on motor and cognitive function and acid-sensing ion channels 1 and 2a in the brains of young and aged male mice(2015-08-01) Kindle, Robbyn S.; Nathalie SumienMetabolic acidosis is a condition in which there is a disruption in the acid/base balance of the body due to an excess of hydrogen ions. This study investigated if in vivo metabolic acidosis lead to brain dysfunction, whether these potential effects were exacerbated with age, and if brain alterations were associated with changes in acid-sensing ion channel (ASIC) 1 and 2a expression. We found that mild chronic acidosis induced by ammonium chloride supplementation resulted in decreased weight in old mice, reversed age-related impairments in motor and cognitive function, and improved spatial learning and memory of young mice. No major alterations were observed in expression of ASIC1 or 2a.