Browsing by Subject "data management"
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Item A Quality Improvement Initiative: Evaluating the Impact of Standardized Data Tracking Tools in the Radiation Oncology Clinical Research Office at the University of Texas Southwestern Medical Center(2022-05) Acevedo, Katalina V.; Mathew, Stephen O.; Ranjan, Amalendu P.Developing preventative measures through intentional planning and oversight of clinical trials has the potential to increase efficiency and quality of trial processes and data. This practicum report details a Quality Improvement (QI) initiative evaluating implementation and impact of a standardized data-tracking software on clinical research data compliance in the Radiation Oncology Clinical Research Office at UT Southwestern Medical Center (UTSW). The standardized data tracker evaluated in this study was built through Quickbase, a cloud-based, low-code application development platform specializing in project management and operations optimization. This project evaluated data sets from two active radiation oncology clinical trials using repeated cross-sectional methods to compare rates of data non-compliance and trends in the types of non-compliance exhibited at baseline, one-month, and three-month post data-tracker implementation. Trends in non-compliance were reviewed and preventative measures backed by recommendations from the literature were proposed to facilitate future QI initiatives within the department. The Chi-Squared (X2) Test for Independence was used to determine whether there was a statistical difference in rates of data non-compliance across the three timepoints within studies and overall followed by post-hoc tests consisting of pairwise comparisons with Bonferroni corrections. Overall, statistical analysis revealed a significant difference in rates on non- compliance across timepoints, suggesting that implementation of the standardized Quickbase data-tracking management tool does significantly decrease rates of non-compliance. Descriptive statistics were performed to characterize the trends in non-compliance within each study across timepoints. This quality improvement project was the first of its kind to formally examine data management trends and practices within the Radiation Oncology Clinical Research Office at UT Southwestern Medical Center. The results provide positive feedback regarding the implementation of a standardized Quickbase data-tracking management tool and characterization of non-compliant data illuminated pressure points in data management workflow that can inform future QI initiatives in shifting data management from its current reactive state to a more proactive data-driven approach. Future work should evaluate the proposed preventative measurements to provide further insight into best practices that can support continuous improvement initiatives within the department.Item CT-based assessment of lower limb surface area, volume, and tissue composition: Implications for ecogeographic rules of thermoregulation(2022-05) Carey, Barclay L.; Maddux, Scott D.; Romero, Steven A.; Gonzales, LaurenAnthropological research into human climatic adaptation has shown that global variation in skin surface-area to body volume ratio is generally consistent with theoretical predictions of ecogeographic rules. NSF has funded a research project in which human subjects will undergo full-body computed tomography scanning, and physiological testing during exposure to climatic extremes, to permit direct evaluation of associations between morphological variation and thermoregulatory physiology. This project entailed the development of analytical methods for the NSF project, which will be used to 1) compare CT-derived SA/V ratios to traditional estimation methods, and 2) to evaluate potential volume differences in internal tissue compositions (e.g., bone, muscle, fat).Item Exploring Freely Available Data Tools to Support Open Data and Open Science(Routledge - Taylor & Francis Group, 2024-01-15) Nieman Hislop, Christine; Pierce Farrier, Katie; Roth, ElizabethLibrarians support researchers by promoting open science and open data practices. This article explores five freely available tools that support and facilitate open science practices. Open Science Framework provides a platform for project management, data sharing, and data storage. OpenRefine cleans and formats data. DMPTool has templates for data management and sharing plans that comply with funder mandates. The NIH Common Data Elements is a repository for standardized data elements, and finally, the NLM Scrubber is a tool for de-identifying clinical text data. Information professionals can add these tools to their repertoire and share them with researchers at their institution.Item Using a Database to Facilitate the Accrual of Geriatric Subjects with Dementia for Clinical Research Studies(2007-04-23) Alexander, Jessica; Patricia Gwirtz; Janice Knebl; Barbara HartyThe internship and practicum project activities took place in an established geriatric practice that provides care to more than 2,000 patients over the age of 65. Research studies and clinical trials conducted at this site are specifically aimed at either testing the efficacy of medications and treatments in the elderly or researching disease processes predominantly found within the older population. This geriatric practice is led by Dr. Janice Knebl with the assistance of Barbara Harty, who is a seasoned geriatric nurse practitioner, IRB board member, clinical coordinator, and my mentor during the internship. The overall objective of the internship was to build a functional knowledge of how to manage research with human subjects. The internship experience spanned several domains within the field of clinical research management: clinical coordination, contract management, institutional research management, and data/records management. Within the course of the internship and implementation of the practicum project there were more than 1040 hours logged working within these areas of concentration in order to achieve that goal. The following is a narrative account of those experiences that details the Internship/Activity Log submitted as Appendix A of this report.