Browsing by Subject "drug resistance"
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Item The Enigmatic Protein Kinase C-eta(MDPI, 2019-02-13) Basu, AlakanandaProtein kinase C (PKC), a multi-gene family, plays critical roles in signal transduction and cell regulation. Protein kinase C-eta (PKCeta) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCeta was shown to regulate cell proliferation, differentiation and cell death. It was also shown to contribute to chemoresistance in several cancers. PKCeta has been associated with several cancers, including renal cell carcinoma, glioblastoma, breast cancer, non-small cell lung cancer, and acute myeloid leukemia. However, mice lacking PKCeta were more susceptible to tumor formation in a two-stage carcinogenesis model, and it is downregulated in hepatocellular carcinoma. Thus, the role of PKCeta in cancer remains controversial. The purpose of this review article is to discuss how PKCeta regulates various cellular processes that may contribute to its contrasting roles in cancer.Item Transmissions of Mycobacterium tuberculosis in Dallas and Tarrant Counties: The Use of RFLP to Evaluate MTB Control Programs(2001-05-01) Kosterman, Edward Donald; Stephen E. Weiss; Terrance GrattonKOSTERMAN, EDWARD DONALD; MASTERS OF PUBLIC HEALTH; MAY 19, 2001 TRANSMISSION OF Mycobacterium tuberculosis IN DALLAS AND TARRANT COUNTIES: THE USE OF RFLP ANALYSIS TO EVALUATE MTB CONTROL PROGRAMS; 108 PAGES; 3 TABLES; 39 REFERENCES Dallas and Tarrant Counties are adjacent, similar counties in North Central Texas. Each county manages MTB patients under similar contracts with the Texas Department of Health. In Dallas county culture positive patients MTB are treated with Selective Directly Observed Therapy. Patients with culture positive MTB in Tarrant county are treated with Universal Directly Observed Therapy. RFLP IS6110-based RFLP analysis revealed that more strains were clustered in Dallas county than Tarrant county. Significantly more drug resistant isolates and drug resistant isolates in clusters were observed in Dallas county. These results suggest that DNA typing methods may be used to assess the efficacy of MTB control programs in areas where traditional epidemiological analysis may be ineffective.