Browsing by Subject "genetic diversity"
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Item Genetic Diversity in Sioux Indians of South Dakota with 21 Autosomal STR Loci and Their Forensic Utility(2015-05-01) Grubb, Nicole C.; Ranajit Chakraborty; Bruce Budowle; Robert C. BarberShort Tandem Repeats are the current standard markers in DNA Forensics. They have been extensively studied in cosmopolitan populations, but not so in small isolated populations, which tend to have unique societal structures impacting their genetic diversity. This project examined 21 autosomal STR loci in Sioux Indians and used NIST data of the same loci on four major U.S. populations to make the comparisons. The study concluded that the Sioux Indians have a reduced genetic diversity at these loci, but this reduction did not compromise their utility for forensic applications for human identification. Genetic diversity analyses of individual Sioux Indian tribes suggested that a pooled database is appropriate for DNA forensic applications.Item Genetic Diversity of Easter Island (Rapanui) Population from Identifiler® Plus autosomal, Y-filer®, and Y-Plex™ 6 Y-STR Loci(2015-05-01) Guadian, Laura; Chakraborty, Ranajit; Budowle, Bruce; Hodge, Lisa M.This study investigated the genetic diversity of the Easter Island (Rapanui) population using data on 15 autosomal Short Tandem Repeats (STRs) typed with the commercial STR kits Identifiler® Plus and 23 Y-chromosome STRs typed using Y-filer (17 loci) and Y- PLEX™ 6 (6 loci). The analysis was conducted using genotype and haplotype data of 122 presumably unrelated individuals that included 48 males and 74 females. This study: (i) examined if Easter Island population had reduced genetic diversity in comparison with cosmopolitan populations such as Mainland Chilean, Polynesian, European, and African; (ii) compared genetic affinity of the Easter Island population with historically related cosmopolitan populations; and (iii) investigated the forensic utility of autosomal STRs and Y-STRs in the Easter Island population.