Browsing by Subject "outcome"
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Item Aging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats(JKL International, 2017-10-01) Pan, Mengxiong; Wang, Peng; Zheng, Chengcai; Zhang, Hongxia; Lin, Siyang; Shao, Bei; Zhuge, Qichuan; Jin, KunlinCompelling evidence indicates that factors in the blood can profoundly reverse aging-related impairments, as exposure of aged mice to young blood rejuvenates adult stem cell function, improves cognition, and ameliorates cardiac hypertrophy. Systemic factors from mice can also extend the life span of a partner exposed to a lethal treatment or disease. These findings suggest that the systemic milieu of a healthy young partner may be beneficial for an aged organism. However, it is unknown whether a healthy young systemic milieu can improve functional recovery after ischemic stroke. Intraperitoneal administration of young plasma into aged rats after ischemic stroke induced by distal middle cerebral artery occlusion (dMCAO) reduced infarct volume and motor impairment, compared with vehicle group. On the contrary, intraperitoneal administration of plasma from aged rats into young ischemic rats worsened brain injury and motor deficits. Using a proteomic approach, we found that haptoglobin levels were significantly increased in serum of aged rats and that intraperitoneal administration of haptoglobin impaired outcome after ischemic stroke in young rats. Our data suggest that the aging systemic milieu plays a critical role in functional outcome after ischemic stroke.Item Review of Blunt Pancreatic Trauma and Its Outcome(2007-12-01) Sanghvi, ChiragSanghvi, Chirag. Review of Blunt Pancreatic Trauma and Its Outcome. Master of Public Health (Biostatistics), December 2007, 37 pp., 4 tables, bibliography, 42 titles. Blunt pancreatic trauma (BPT) is an uncommon injury involving 1%-2% of blunt abdominal traumas but it can be associated with a high complication rate. Various studies have shown complication rate to range from 30%-64% following blunt pancreatic injury. With Institutional Review Board (IRB) approval a retrospective chart review study was performed for last 12 years. Chart review failed to support the hospital assigned diagnosis of BPT in 3 patients, leaving 37 cases for analysis. BPT had an overall mortality rate of 22%. In the patients surviving the injury, early surgical intervention (≤12 hours) had a complication rate of 31% versus 57% for delayed surgical intervention ([greater than] 12 hours). BPT has a high mortality rate but is usually secondary to other organs involved in the injury. Delayed surgical intervention has a higher complication rate compared to early intervention.