Browsing by Subject "ovarian cancer"
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Item Clinical Internship with the Division of Gynecologic Oncology at UT Southwestern Medical Center: Carboplatin and Doxil for Gynecologic Cancers(2003-12-01) Epps, Camitria N.; Victoria Rudick; David S. Miller; Barbara RichardsonEpps, Camitria N., Master of Science, Clinical Research Management, December 2003, Carboplatin and Doxil for Gynecologic Cancers, 107 Pages, 9 Tables, 42 titles in Bibliography. Objective: To examine the safety and efficacy of administering the drugs carboplatin and doxil in combination chemotherapy for the treatment of gynecologic cancers, mainly endometrial and ovarian cancer. Materials and Methods: Carboplatin and doxil were previously administered intravenously to 6 patients. Each patient received 3 to 8 cycles of chemotherapy. Doses of carboplatin ranged from 310 mg to 665 mg. The doses of doxil ranged from 54 mg to 80 mg. This is a retrospective study. The 6 patient’s medical charts were reviewed. Data was extracted and a spreadsheet formatted database was created. Results: Data were extracted and a spreadsheet formatted database was created. Results: Due to the small number of patients the results are not statistically significant. 2 patients showed tumor progression while receiving treatment. All patients tolerated doses very well and experienced minimal toxicities. Conclusion: Carboplatin plus doxil combination chemotherapy given intravenously has a potent effect on endometrial and ovarian cancers. Studies using this chemotherapy for the treatment of gynecologic cancers should be conducted on a wider scale to access the statistical significance of the treatment.Item The Relationship Between Atrazine Exposure and Breast and Ovarian Cancer Incidence Rates in Texas Agricultural Statistical Districts(2006-05-01) Hull, Kimberly M.; Terrance Gratton; Eric Johnson; Sejong BaeHull, Kimberly M., The Relationship Between Atrazine Exposure and Breast and Ovarian Cancer Incidence Rates in Texas Agricultural Statistical Districts. Masters of Public Health (Environmental Health), May 2006, 95pp., 16 tables, 7 illustrations, reference, 74 titles. The herbicide, atrazine, is suspected to cause cancer primarily through drinking water. This ecological study analyzed relationships between potential atrazine exposures and female breast and ovarian cancer incidence rates in Texas Agricultural Statistical Districts. Atrazine exposures are: atrazine usage, rural population, and public water systems. Study results indicate an inverse relationship between four atrazine exposures and breast and ovarian cancer incidence rates (county level). There is a positive relationship between surface water systems and ovarian cancer incidences rates (county level). There also is an inverse relationship between one atrazine usage index and ovarian cancer incidence rates (district level). Study results are similar to other atrazine and cancer studies; correlations prevent statements of causal inference.