Browsing by Subject "smoking"
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Item Interleukin-6 and its Relationship to Coronary Artery Calcium Burden-North Texas Healthy Heart Study(2008-05-01) AbdulRahim, Nashila; Roberto Cardarelli; Sejong Bae; Richard VirgilioAbdulRahim, Nashila, Interleukin-6 and its Relationship to Coronary Artery Calcium Burden- North Texas Healthy Heart Study. Master of Science (Primary Care Clinical Research), May, 2008, pp., 7 tables, 5 figures, bibliography, 73 titles. Atherosclerosis is highly associated with increased serum inflammatory markers. Coronary artery calcium (CAC) burden has allowed researchers to have a non-invasive proxy measure of atherosclerosis. We hypothesized that interleukin-6 (IL-6), after controlling for CV risk factors, would be associated with CAC scores, and this association will be modified by race/ethnicity. 344 subjects were recruited. IL-6 concentrations were measured, and computed tomography was used to calculate CAC scores. After accounting for age, gender, race, smoking, hypertension, diabetes, and cholesterol, a one-unit increase in IL-6 concentration is associated with 1.03 greater odds of an abnormal calcium score (OR: 1.03, 95% CI: 0.98, 1.07). Race/ethnicity did not modify this association. IL-6 did not prove to be a simple clinical marker of CAC.Item The Color of Smoke: An Examination of the Relationship between Menthol Cigarettes and Youth Smoking(2009-05-01) Garner, William A.; Dr. Kristine LykensBackground. Research on the use and effect of menthol content in cigarettes is well established. More recent is research on the effect of menthol content on the smoking habits of school-aged youth. This study examined the relationship between menthol content and current cigarette use to test whether menthol content is predictive of current cigarette use among school-aged youth. Methods. This study included all respondents to the 2004 National Youth Tobacco Survey who were 17 years old and younger and who indicated they were current smokers. Ordinal and generalized logistic regressions were used to estimate the relationship between menthol content and current cigarette use, controlling for sociocontextual and demographic factors. All analyses were performed in STATA 10. Results. In general, menthol content has a positive but not statistically significant effect on current cigarette use, controlling for sociocontextual factors. However, menthol content has a positive and statistically significant effect on days smoked (OR=1.2; p=0.046), on current cigarette use, controlling for demographic factors (OR=1.3; p=0.011); and on current cigarette use for light smokers (OR=1.3; p [less than] 0.001) and heavy smokers (OR=2.3; p [less than] 0.001), controlling for demographic factors. Conclusion: More research is needed to understand the true effect of menthol content on the smoking habits of school-aged youth across the smoking continuum.