Browsing by Subject "tissue engineering"
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Item Adipose Stem Cells in Regenerative Medicine: Looking Forward(Frontiers Media S.A., 2022-01-13) Al-Ghadban, Sara; Artiles, Maria; Bunnell, Bruce A.Over the last decade, stem cell-based regenerative medicine has progressed to clinical testing and therapeutic applications. The applications range from infusions of autologous and allogeneic stem cells to stem cell-derived products. Adult stem cells from adipose tissue (ASCs) show significant promise in treating autoimmune and neurodegenerative diseases, vascular and metabolic diseases, bone and cartilage regeneration and wound defects. The regenerative capabilities of ASCs in vivo are primarily orchestrated by their secretome of paracrine factors and cell-matrix interactions. More recent developments are focused on creating more complex structures such as 3D organoids, tissue elements and eventually fully functional tissues and organs to replace or repair diseased or damaged tissues. The current and future applications for ASCs in regenerative medicine are discussed here.Item Strategy to Design a Stratified Corneal Stroma Construct(2008-07-01) Arafeh, Reem B.; Dan Dimitrijevich; Ignacy Gryczynski; Harlan JonesArafeh, Reem B., Strategy to Design a Stratified Lamellar Corneal Stroma Construct. Master of Science (Biomedical Sciences), July 2nd, 2008, 103pp., 1 table, 42 illustrations, bibliography, 63 titles. Cornea is the transparent portion of the eye. Its three cellular compartments: the epithelium, stroma, and endothelium, are optimized for transparency and focusing. Although corneal grafting with donor corneas is a successful treatment to restore vision, there is an acute shortage of appropriate quality donor tissue. Tissue engineering is a new approach that addresses this shortage. In this thesis it was demonstrated that lamellar stromal structure is reproduced by stacking thin collagen films. Collagen fibril organization in the thin films directs cellular alignment allowing assembly of an orthogonal stroma construct that transmits more light than most other published constructs and is optically active. Whereas the cell alignment and lamellar arrangement were successful, optimization of optical properties is a major future goal.