Meta-analysis of modifiable risk factors contributing to incidence of permanent pacemaker implantation following Transcatheter Aortic Valve Replacement

Meta-analysis of modifiable risk factors contributing to incidence of permanent pacemaker implantation following Transcatheter Aortic Valve Replacement By: Ariella Azimi, Justin Salman, and Dr. Scott Ewing Purpose: To conduct a meta-analysis of existing literature investigating risk factors contributing to permanent pacemaker implantation following Transcatheter Aortic Valve Replacement (TAVR), including type of TAVR device, depth of implantation, and membranous septal length. Methods: Perform systematic search of studies using PubMed and Google Scholar that investigate post-TAVR pacemaker placement and provide data on predictors of interest. Summary relative risk and 95% CI for each predictor variable calculated using random effects model. Results: We predict that the type of TAVR device used, depth of implantation, and membranous septal length correlate with the incidence of pacemaker placement in congruence with trends outlined in existing literature but with greater statistical power. Conclusion: Using the result of this meta-analysis, we hope to provide insight into modifiable preprocedural and intraprocedural risk factors that may contribute to future studies affecting the guidelines of TAVR procedures.