Selection of an Ancestry-Informative Marker (AIM) Panel of INDELs

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dc.contributor.advisorLaRue, Bobby L.
dc.contributor.committeeMemberHodge, Lisa M.
dc.contributor.committeeMemberOglesby, Michael
dc.creatorThompson, Lindsey M.
dc.date.accessioned2019-08-22T21:18:19Z
dc.date.available2019-08-22T21:18:19Z
dc.date.issued2015-05-01
dc.date.submitted2015-07-08T08:36:33-07:00
dc.description.abstractShort Tandem Repeat (STR) loci are commonly used for forensic identification purposes. Most commercially available STR kits yield amplified fragments with lengths between 100 and 600 base pairs (bp). However, the genomic DNA of forensic samples can be highly degraded, yielding incomplete STR profiles. Small insertion/deletion polymorphisms (INDELs) in the intergenic regions of the genome, are viable options for typing degraded samples. Furthermore, when there are no suspects for comparison, ancestry-informative markers (AIMs) are useful for developing investigative leads. This project tested the hypothesis that using publicly available genome data, a panel of AIM-INDELs can be selected for the purposes of distinguishing the Caucasian, East Asian and African population groups. To test this hypothesis, the data from the 1000 Genomes Project were mined to select a panel of AIMs that can be used for the purposes of providing ancestry information as an investigative lead to law enforcement.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29230
dc.language.isoen
dc.provenance.legacyDownloads128
dc.subjectForensic Science and Technology
dc.subjectGenetic Processes
dc.subjectGenetic Structures
dc.subjectGenomics
dc.subjectMedical Sciences
dc.subjectMedicine and Health Sciences
dc.subjectMolecular Genetics
dc.subjectINDELs
dc.subjectforensics
dc.subjectancestry-informative markers
dc.titleSelection of an Ancestry-Informative Marker (AIM) Panel of INDELs
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineForensic Genetics
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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