Regional Adipose Tissue Deposition, Its Rate of Lipolysis, and Subsequent Effect of Insulin Resistance-in Type II Diabetes Mellitus

dc.contributor.advisorRaven, Peter B.
dc.contributor.committeeMemberDowney, H. Fred
dc.contributor.committeeMemberCaffrey, James L.
dc.creatorSchalscha, Alan G.
dc.description.abstractDiabetes mellitus is a disease that plagues populations world wide. More than 5 percent of U.S. citizens are afflicted with one or another form of this disease (22). This paper begins by discussing the incidence of this illness as it affects Americans. An explanation of the four forms in which diabetes mellitus itself will be offered, and these will be classified according to etiology. Non-insulin dependent diabetes mellitus (NIDDM), also called type II diabetes mellitus, will be the last of these forms mentioned. Due to its prevalence, NIDDM will be the focus of this paper. The proposed pathophysiology of NIDDM will be discussed, though to researchers it still remains somewhat of a mystery. This paper will then briefly the genetic and environmental interaction responsible for the onset of non-insulin dependent diabetes mellitus. A brief discussion of the interrelationship between decreasing physical activity and a subsequent increase in obesity will follow (38). The location of adipose tissue seems to have adverse effects on certain aspects of NIDDM, including its sensitivity to insulin. This paper proposes that either subcutaneous or visceral adipose deposits specifically reduce insulin sensitivity more than other fat stores. The connection between adipose tissue and insulin sensitivity appears to be mediated by fatty acids released from specific depots and their destination immediately following release.
dc.subjectClinical Epidemiology
dc.subjectExercise Science
dc.subjectHemic and Immune Systems
dc.subjectHemic and Lymphatic Diseases
dc.subjectMedicine and Health Sciences
dc.subjectNutritional and Metabolic Diseases
dc.subjectPublic Health
dc.subjectSystems and Integrative Physiology
dc.subjectDiabetes mellitus
dc.subjectnon-insulin dependent
dc.subjecttype II
dc.subjectphysical activity
dc.subjectsubcutaneous deposits
dc.subjectvisceral adipose deposits
dc.subjectfat stores
dc.subjectadipose tissue
dc.subjectinsulin sensitivity
dc.subjectfatty acids
dc.titleRegional Adipose Tissue Deposition, Its Rate of Lipolysis, and Subsequent Effect of Insulin Resistance-in Type II Diabetes Mellitus
dc.typeProfessional Report
dc.type.materialtext School of Biomedical Sciences of North Texas Health Science Center at Fort Worth of Science


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