The impact of early life stressors on the progression of SLE

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dc.contributor.advisorMathis, Keisa W.
dc.contributor.committeeMemberCunningham, J. Thomas
dc.contributor.committeeMemberHodge, Lisa M.
dc.contributor.committeeMemberTune, Johnathan D.
dc.creatorHartman, Rusty L.
dc.date.accessioned2022-10-26T15:26:26Z
dc.date.available2022-10-26T15:26:26Z
dc.date.issued2021-08
dc.description.abstractOur preliminary studies show that an established model of systemic lupus erythematosus (SLE), the female NZBWF1 mouse, had worsened indices of disease later in life when the mice were shipped to our institution at an early age during the summer. We hypothesized that interleukin (IL)-6-induced release of heat shock protein 90 (HSP90) is upregulated in response to this summer early-life stressor, thus accelerating autoimmunity and renal disease in female SLE mice. To begin to study this, we measured renal IL-6 and HSP90 in 6-week-old female NZBWF1 mice that were shipped in winter or summer months and found that both were elevated immediately following summer compared to winter travel. Our findings indicate that the mediators associated with early-life travel/seasonal stressors may predict the progression of autoimmunity in SLE-prone mice. Other findings here within highlight the specificity of this effect in the kidney and describe sex differences in the observed phenomena.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31889
dc.language.isoen
dc.subjectearly life stress
dc.subjectenvironmental stress
dc.subjectHSP90
dc.subjectIL-6
dc.subjectSLE
dc.subject.meshLupus Erythematosus, Systemic
dc.subject.meshStress, Physiological
dc.titleThe impact of early life stressors on the progression of SLE
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentSchool of Biomedical Sciences
thesis.degree.disciplineIntegrative Physiology
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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