A Look at Diabetes Mellitus and the Effects of a Study Drug on Diabetic Nephropathy

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dc.contributor.advisorDebbie Lewis
dc.contributor.committeeMemberClifton Cage
dc.contributor.committeeMemberRustin Reeves
dc.creatorSchlueter, Cynthia K.
dc.date.accessioned2019-08-22T21:12:56Z
dc.date.available2019-08-22T21:12:56Z
dc.date.issued2002-08-01
dc.date.submitted2014-03-31T08:48:16-07:00
dc.description.abstractDuring my internship, I assisted with a twenty-four week, phase 2, double blinded, placebo controlled trial for a drug being developed to slow, if not prevent, the development of ESRD from overt neuropathy in patients with both type 1 and type 2 diabetes. This drug is a naturally occurring component of vitamin B6 and is an AGE-inhibitor. The AGE-inhibitory effect of the study drug was discovered by isolating Amadori products in the pathway to AGE formation. Once the intermediates were isolated, the sponsor’s scientists searched for compounds that could specifically block the conversion of these Amadori products into AGEs. The study drug was found to be a strong inhibitor of this pathway. In comparison, the common AGE inhibitor, aminoguanidine was found to be ineffective in blocking the post-Amadori foundation AGEs. Therefore, it must block AGE formation at one of the less clinically relevant pathways, and should be less effective in treating nephropathy according to the sponsor’s scientists. This study included type 1 and type 2 patients with clinically diagnosed diabetic retinopathy and a urinary albumin excretion rate (UAE) of greater than 300 mg/24h. Other inclusion and exclusion criteria were applied for the safety of the subjects and greater viability of the data.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29161
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectClinical Epidemiology
dc.subjectDiseases
dc.subjectEpidemiology
dc.subjectHemic and Immune Systems
dc.subjectHemic and Lymphatic Diseases
dc.subjectMedicine and Health Sciences
dc.subjectNutritional and Metabolic Diseases
dc.subjectPublic Health
dc.subjectDrug trial
dc.subjecttype 1 diabetes
dc.subjecttype 2 diabetes
dc.subjectvitamin B6
dc.subjectAGE inhibitor
dc.subjectaminoguanidine
dc.subjectpost-Amadori foundation
dc.subjectAGE formation
dc.subjectdiabetic retinopathy
dc.subjecturinary albumin excretion rate
dc.titleA Look at Diabetes Mellitus and the Effects of a Study Drug on Diabetic Nephropathy
dc.typeProfessional Report
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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