Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study

Simple item page
dc.creatorO'Bryant, Sid E.
dc.creatorZhang, Fan
dc.creatorPetersen, Melissa E.
dc.creatorHall, James R.
dc.creatorJohnson, Leigh A.
dc.creatorYaffe, Kristine
dc.creatorBraskie, Meredith N.
dc.creatorRissman, Robert A.
dc.creatorVig, Rocky
dc.creatorToga, Arthur W.
dc.creator.orcid0000-0003-0582-5266 (O'Bryant, Sid E.)
dc.creator.orcid0000-0001-7769-8417 (Johnson, Leigh A.)
dc.creator.orcid0000-0002-3920-5877 (Petersen, Melissa E.)
dc.date.accessioned2022-07-07T13:54:27Z
dc.date.available2022-07-07T13:54:27Z
dc.date.issued2022-02-09
dc.description.abstractIntroduction: We sought to examine a magnetic resonance imaging (MRI)-based marker of neurodegeneration from the AT(N) (amyloid/tau/neurodegeneration) framework among a multi-ethnic, community-dwelling cohort. Methods: Community-dwelling Mexican Americans and non-Hispanic White adults and elders were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing and 3T MRI of the brain. A neurodegeneration MRI meta-region of interest (ROI) biomarker for the AT(N) framework was calculated. Results: Data were examined from n = 1305 participants. Mexican Americans experienced N at significantly younger ages. The N biomarker was significantly associated with cognitive outcomes. N was significantly impacted by cardiovascular factors (e.g., total cholesterol, low-density lipoprotein) among non-Hispanic Whites whereas diabetes (glucose, HbA1c, duration of diabetes) and sociocultural (household income, acculturation) factors were strongly associated with N among Mexican Americans. Discussion: The prevalence, progression, timing, and sequence of the AT(N) biomarkers must be examined across diverse populations.
dc.description.sponsorshipResearch reported here was supported by the National Institute on Aging of the National Institutes of Health under Award Numbers R01AG054073 and R01AG058533. This work was also supported in part by NIH/NIBIB award P41-EB015992.
dc.identifier.citationO'Bryant, S. E., Zhang, F., Petersen, M., Hall, J., Johnson, L. A., Yaffe, K., Braskie, M., Rissman, R. A., Vig, R., Toga, A. W., & HABLE Study Team (2022). Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study. Alzheimer's & dementia (Amsterdam, Netherlands), 14(1), e12267. https://doi.org/10.1002/dad2.12267
dc.identifier.issn2352-8729
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31538
dc.identifier.volume14
dc.publisherWiley Periodicals, LLC
dc.relation.urihttps://doi.org/10.1002/dad2.12267
dc.rights.holderCopyright © 2021 The Authors.
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceAlzheimer's & Dementia Diagnosis, Assessment & Disease Monitoring
dc.subjectAlzheimer's disease
dc.subjectHispanic
dc.subjectdiversity
dc.subjectmild cognitive impairment
dc.subjectneurodegeneration
dc.subject.meshAlzheimer Disease
dc.subject.meshCognitive Dysfunction
dc.subject.meshMexican Americans
dc.subject.meshAmyloid
dc.subject.meshBiomarkers
dc.titleNeurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study
dc.typeArticle
dc.type.materialtext

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
10.1002_dad2.12267.pdf
Size:
453.01 KB
Format:
Adobe Portable Document Format
Description:
full text article
Download

Collections

Publications -- Sid E. O'Bryant
Publications -- Fan Zhang
Publications -- James R. Hall
Publications -- Leigh A. Johnson
Publications -- Melissa E. Petersen