Clinical significance of Annexin A2 overexpression in kidney renal clear cell carcinoma




Joseph, Matthew
Chaudhary, Pankaj


0000-0001-7777-1258 (Joseph, Matthew)
0000-0003-0518-4120 (Chaudhary, Pankaj)

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Purpose: Invasion and metastasis led to poor prognosis and death of kidney renal clear cell carcinoma (KIRC) patients. In this study, we focus on the characterization of Annexin A2 (AnxA2), which plays an essential role in cell growth, angiogenesis, migration, invasion, and metastasis. Although the role of Annexin A2 (AnxA2) has been studied in many cancers, its function in KIRC is still unexplored. Therefore, in this study, we investigated the AnxA2 expression in tumor tissues of KIRC patients to determine its association with disease characteristics.

Methods: We utilized data from The Cancer Genome Atlas (TCGA) to observe AnxA2 gene expression in KIRC and its association with survival. Additionally, immunohistochemical (IHC) analysis was performed to examine the AnxA2 expression in tumor tissues of KIRC patients.

Results: In our analysis of TCGA data, AnxA2 mRNA expression was found significantly higher in KIRC tumor tissues compared to the adjacent noncancerous tissues. In addition, AnxA2 expression was significantly associated with higher tumor stage and grade. The high expression of AnxA2 in KIRC patients was significantly correlated to decreased survival [hazard ratio (HR), 1.75; 95% confidence interval (CI), 1.29 - 2.36; p = 0.00023] as compared to low expression. In addition, our IHC staining suggests that AnxA2 was overexpressed in tumor tissues of KIRC patients compared with adjacent noncancerous tissues.

Conclusion: AnxA2 is overexpressed in KIRC tumor tissues, and has a direct relationship to the advanced clinicopathological variables and adverse prognosis associated to patients with KIRC.