Indications of musculoskeletal health in deceased male individuals with lower-limb amputations: comparison to non-amputee and diabetic controls

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dc.creatorFinco, M. G.
dc.creatorFinnerty, Caitlyn
dc.creatorNgo, Wayne
dc.creatorMenegaz, Rachel A.
dc.creator.orcid0000-0002-7261-7873 (Menegaz, Rachel A.)
dc.date.accessioned2023-06-07T18:15:35Z
dc.date.available2023-06-07T18:15:35Z
dc.date.issued2023-06-01
dc.description.abstractIndividuals with lower-limb amputations, many of whom have type 2 diabetes, experience impaired musculoskeletal health. This study: (1) compared residual and intact limbs of diabetic and non-diabetic post-mortem individuals with amputation to identify structures vulnerable to injury, and (2) compared findings to diabetic and healthy control groups to differentiate influences of amputation and diabetes on musculoskeletal health. Postmortem CT scans of three groups, ten individuals each, were included: (1) individuals with transtibial or transfemoral amputations, half with diabetes (2) diabetic controls, and (3) healthy controls. Hip and knee joint spaces, cross-sectional thigh muscle and fat areas, and cross-sectional bone properties (e.g. area, thickness, geometry) were measured. Wilcoxon Signed-Rank and Kruskal-Wallis tests assessed statistical significance. Asymmetry percentages between limbs assessed clinical significance. Residual limbs of individuals with amputation, particularly those with diabetes, had significantly less thigh muscle area and thinner distal femoral cortical bone compared to intact limbs. Compared to control groups, individuals with amputation had significantly narrower joint spaces, less thigh muscle area bilaterally, and thinner proximal femoral cortical bone in the residual limb. Diabetic individuals with amputation had the most clinically significant asymmetry. Findings tended to align with those of living individuals. However, lack of available medical information and small sample sizes reduced the anticipated clinical utility. Larger sample sizes of living individuals are needed to assess generalizability of findings. Quantifying musculoskeletal properties and differentiating influences of amputation and diabetes could eventually help direct rehabilitation techniques.
dc.description.sponsorshipThe Free Access Decedent Database was funded by the National Institute of Justice grant number 2016-DN-BX0144. MGF was supported by the National Institutes of Health/National Institute on Aging (T32 AG020494) and the Institute for Healthy Aging. CF was supported by the Summer Opportunities in Anatomy Research at the University of North Texas Health Science Center through the American Association for Anatomy Innovations Program.
dc.identifier.citationFinco, M. G., Finnerty, C., Ngo, W., & Menegaz, R. A. (2023). Indications of musculoskeletal health in deceased male individuals with lower-limb amputations: comparison to non-amputee and diabetic controls. Scientific reports, 13(1), 8838. https://doi.org/10.1038/s41598-023-34773-w
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32367
dc.identifier.volume13
dc.publisherSpringer Nature
dc.relation.urihttps://doi.org/10.1038/s41598-023-34773-w
dc.rights.holder© The Author(s) 2023
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientific Reports
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshDiabetes Mellitus, Type 2 / surgery
dc.subject.meshAmputation, Surgical
dc.subject.meshLower Extremity / surgery
dc.subject.meshFemur / surgery
dc.subject.meshKnee
dc.subject.meshArtificial Limbs
dc.subject.meshAmputees
dc.titleIndications of musculoskeletal health in deceased male individuals with lower-limb amputations: comparison to non-amputee and diabetic controls
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dc.type.materialArticle

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