Neuroprotective effects of peroxisome proliferator-activated receptor-gamma (PPAR-y) ligands against oxidative stress

Simple item page
dc.contributor.advisorSimpkins, James W.
dc.contributor.committeeMemberDillon, Glenn
dc.contributor.committeeMemberGracy, Robert
dc.creatorAoun, Paul
dc.date.accessioned2019-08-22T21:10:35Z
dc.date.available2019-08-22T21:10:35Z
dc.date.issued2003-12-01
dc.date.submitted2013-06-06T07:00:09-07:00
dc.description.abstractAoun, Paul Neuroprotective effects of peroxisome proliferator-activated receptor-gamma (PPAR-y) ligands against oxidative stress. Doctor of Philosophy (Pharmacology and Neurosciences), December, 2003, 254 pp., 37 figures. Diabetes mellitus is a significant public health problem in the United States and the world resulting in substantial morbidity and mortality. Diabetes complications, i.e., neuropathy, are common and almost triple the annual cost of managing diabetes. In our studies, we investigated the role that insulin sensitizers currently used for the treatment of diabetes, the PPAR-y ligands, might play in protecting neurons against oxidative stresses. We showed that two PPAR-y ligands, 15 deoxy-PGJ2 and troglitazone, protected, in a dose-dependent manner, HT-22 mouse hippocampal and RGC-5 retinal ganglion cell lines against various oxidative insults. Further, we demonstrated that neuroprotection by 15deoxy-PGJ2 and troglitazone was independent of the PPAR-y receptor. Our findings brought to light an important role of PPAR-y ligands in preventing neuronal complications from diabetes. Moreover, the studies reported herein provide valuable insights into the development of novel therapeutic compounds that improve insulin sensitivity while preventing neurological, and possibly other complications of diabetes.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29130
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectDiseases
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.subjectNeuroscience and Neurobiology
dc.subjectNutritional and Metabolic Diseases
dc.subjectOther Neuroscience and Neurobiology
dc.subjectPublic Health
dc.subjectRehabilitation and Therapy
dc.subjectDiabetes mellitus
dc.subjectpublic health
dc.subjectcomplications
dc.subjectcosts
dc.subjecttreatment
dc.subjectinsulin sensitizers
dc.subjectPPAR-y ligands
dc.subjectoxidative stresses
dc.titleNeuroprotective effects of peroxisome proliferator-activated receptor-gamma (PPAR-y) ligands against oxidative stress
dc.typeDissertation
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplinePharmacology and Neuroscience
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameDoctor of Philosophy

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Aoun_NeuroprotectiveEffectsOfPeroxisome.pdf
Size:
100.69 MB
Format:
Adobe Portable Document Format
Download

Collections

School of Biomedical Sciences
Theses and Dissertations