The Effects of Hyperlipidemia and Hypoglycemia on Myocardial Contractile Function and Oxygen Utilization During Coronary Hypoperfusion

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dc.contributor.advisorDowney, H. Fred
dc.contributor.committeeMemberMallet, Robert T.
dc.contributor.committeeMemberSmith, Michael B.
dc.creatorHart, Bradley Joe
dc.date.accessioned2019-08-22T19:42:33Z
dc.date.available2019-08-22T19:42:33Z
dc.date.issued1998-08-01
dc.date.submitted2014-02-04T08:44:39-08:00
dc.description.abstractHart, Bradley Joe, The Effects of Hyperlipidemia and Hypoglycemia on Myocardial Contractile Function and Oxygen Utilization During Coronary Hypoperfusion Master of Science (Biomedical Sciences), August, 1998, 85 pp., 1 table, 5 figures, references, 51 titles. This study was designed to determine the effects of elevated fatty acid and lowered glucose concentrations on myocardial contractile function and substrate selection during hypoperfusion. Coronary perfusion pressure (CPP) was lowered in the left anterior descending coronary artery of open-chest anesthetized dogs. Glucose uptake, fatty acid uptake, and percent segment shortening (%SS) were determined with normal arterial FFA concentrations (Group 1) or with elevated concentrations (Groups 2 and 3). When glucose was removed by dialysis in Group 3, FFA uptake increased and glucose uptake decreased relative to Group 1 at 40 mmHg CPP (p [less than] 0.05). Oxygen consumption significantly increased (p [less than] 0.05); however, %SS was unchanged. Thus, although the myocardium switches from fatty acid to glucose metabolism to increase oxygen utilization efficiency during hypoperfusion, blocking this switch does not contribute to a further decrease in myocardial contractile function.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/26780
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectCardiology
dc.subjectCardiovascular System
dc.subjectCirculatory and Respiratory Physiology
dc.subjectComparative and Laboratory Animal Medicine
dc.subjectLife Sciences
dc.subjectMedical Physiology
dc.subjectMedicine and Health Sciences
dc.subjectPhysiological Processes
dc.subjectPhysiology
dc.subjectVeterinary Medicine
dc.subjectVeterinary Physiology
dc.subjectHyperlipidemia
dc.subjecthypoglycemia
dc.subjectmyocardial contractile function
dc.subjectoxygen utilization
dc.subjectcoronary hypoperfusion
dc.subjecteffects
dc.subjectelevated fatty acid
dc.subjectlowered glucose concentrations
dc.subjectcoronary perfusion pressure
dc.subjectdogs
dc.subjectglucose metabolism
dc.titleThe Effects of Hyperlipidemia and Hypoglycemia on Myocardial Contractile Function and Oxygen Utilization During Coronary Hypoperfusion
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentSchool of Public Health
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Public Health

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