Moderation effects of serotype on dengue severity across pregnancy status in Mexico

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dc.creatorAnnan, Esther
dc.creatorNguyen, Uyen-Sa D. T.
dc.creatorTrevino, Jesus
dc.creatorWan Yaacob, Wan F.
dc.creatorMangla, Sherry
dc.creatorPathak, Ashok K.
dc.creatorNandy, Rajesh
dc.creatorHaque, Ubydul
dc.creator.orcid0000-0003-2715-9073 (Nguyen, Uyen-Sa D. T.)
dc.creator.orcid0000-0002-7413-1017 (Haque, Ubydul)
dc.date.accessioned2023-03-27T15:24:24Z
dc.date.available2023-03-27T15:24:24Z
dc.date.issued2023-03-11
dc.description.abstractBACKGROUND: Pregnancy increases a woman's risk of severe dengue. To the best of our knowledge, the moderation effect of the dengue serotype among pregnant women has not been studied in Mexico. This study explores how pregnancy interacted with the dengue serotype from 2012 to 2020 in Mexico. METHOD: Information from 2469 notifying health units in Mexican municipalities was used for this cross-sectional analysis. Multiple logistic regression with interaction effects was chosen as the final model and sensitivity analysis was done to assess potential exposure misclassification of pregnancy status. RESULTS: Pregnant women were found to have higher odds of severe dengue [1.50 (95% CI 1.41, 1.59)]. The odds of dengue severity varied for pregnant women with DENV-1 [1.45, (95% CI 1.21, 1.74)], DENV-2 [1.33, (95% CI 1.18, 1.53)] and DENV-4 [3.78, (95% CI 1.14, 12.59)]. While the odds of severe dengue were generally higher for pregnant women compared with non-pregnant women with DENV-1 and DENV-2, the odds of disease severity were much higher for those infected with the DENV-4 serotype. CONCLUSION: The effect of pregnancy on severe dengue is moderated by the dengue serotype. Future studies on genetic diversification may potentially elucidate this serotype-specific effect among pregnant women in Mexico.
dc.description.sponsorshipThere was no funding for this study. U.H. was supported by Rutgers Global Health Institute.
dc.identifier.citationAnnan, E., Nguyen, U. D. T., Treviño, J., Wan Yaacob, W. F., Mangla, S., Pathak, A. K., Nandy, R., & Haque, U. (2023). Moderation effects of serotype on dengue severity across pregnancy status in Mexico. BMC infectious diseases, 23(1), 147. https://doi.org/10.1186/s12879-023-08051-z
dc.identifier.issn1471-2334
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32064
dc.identifier.volume23
dc.publisherBioMed Central Ltd.
dc.relation.urihttps://doi.org/10.1186/s12879-023-08051-z
dc.rights.holder© The Author(s) 2023.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceBMC Infectious Diseases
dc.subjectDengue
dc.subjectreproductive age
dc.subjectserotype
dc.subjectsevere
dc.subjectseverity
dc.subjectwomen
dc.subjectMexico
dc.subject.meshHumans
dc.subject.meshFemale
dc.subject.meshPregnancy
dc.subject.meshSevere Dengue
dc.subject.meshSerogroup
dc.subject.meshDengue
dc.subject.meshDengue Virus / genetics
dc.subject.meshMexico
dc.subject.meshCross-Sectional Studies
dc.subject.meshSerotyping
dc.titleModeration effects of serotype on dengue severity across pregnancy status in Mexico
dc.typeArticle
dc.type.materialtext

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