Modulation of Manganese Superoxide Dismutase by 17-Beta Estradiol

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dc.contributor.advisorThomas Yorio
dc.creatorGottipati, Srinivas
dc.date.accessioned2019-08-22T21:38:38Z
dc.date.available2019-08-22T21:38:38Z
dc.date.issued2008-05-01
dc.date.submitted2014-02-04T08:44:39-08:00
dc.description.abstractGottipati, Srinivas. Modulation of manganese superoxide dismutase activity by 17-beta estradiol. Master of Science (Cell Biology and Genetics), May, 2008. We have previously reported that 17β-Estradiol (17β-E2) can protect human lens epithelial cells against oxidative stress by preserving mitochondrial function, acting as a positive regulator of the MAPK signal transduction pathway. While pERK plays a significant role in stabilizing the inner mitochondrial membrane to maintain the mitochondrial membrane potential during oxidative stress, the protective mechanisms activated by 17β-E2 are probably multifactorial acting via both genomic and non genomic pathways. This study examined the effects of 17β-E2 on the expression and activity of MnSOD, which is present exclusively in the mitochondria, as a possible mechanism by which it affords protection against oxidative stress. Our results demonstrate that 17β-E2 rapidly increases the activity of MnSOD in a time dependent manner. This augmentation of activity of MnSOD by 17β-E2 is seen in the absence of a corresponding increase in the mRNA and protein expression, thereby which estrogens protect the cells against oxidative stress will help us in developing estrogens to be useful therapies for the prevention of cataract in postmenopausal women and non feminizing estrogens may provide similar protection in men.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29481
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectCell Anatomy
dc.subjectCell and Developmental Biology
dc.subjectCell Biology
dc.subjectCells
dc.subjectCellular and Molecular Physiology
dc.subjectLife Sciences
dc.subjectMedical Cell Biology
dc.subjectMedicine and Health Sciences
dc.subjectOphthalmology
dc.subjectOptometry
dc.subjectOther Cell and Developmental Biology
dc.subjectSense Organs
dc.subjectVision Science
dc.subjectModulation
dc.subjectmanganese superoxide dismutase activity
dc.subject17-beta estradiol
dc.subject17β-E2
dc.subjecthuman lens epithelial cells
dc.subjectoxidative stress
dc.subjectMAPK signal transduction pathway
dc.subjectmitochondrial membrane
dc.subjectMnSOD
dc.subjectestrogens
dc.subjectcataract
dc.subjectpostmenopausal women
dc.subjectnon-feminizing estrogen
dc.titleModulation of Manganese Superoxide Dismutase by 17-Beta Estradiol
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineCell Biology and Genetics
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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