Hypoxia, hibernation and Neuroprotection: An Experimental Study in Mice

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dc.creatorRen, Changhong
dc.creatorLi, Sijie
dc.creatorRajah, Gary
dc.creatorShao, Guo
dc.creatorLu, Guowei
dc.creatorHan, Rongrong
dc.creatorHuang, Qingjian
dc.creatorLi, Haiyan
dc.creatorDing, Yuchuan
dc.creatorJin, Kunlin
dc.creatorJi, Xunming
dc.creator.orcid0000-0002-1336-348X (Jin, Kunlin)
dc.date.accessioned2022-09-09T14:08:41Z
dc.date.available2022-09-09T14:08:41Z
dc.date.issued2018-08-01
dc.description.abstractHibernation is a unique physiological state that evolved to survive periods of food shortages. It is characterized by profound decreases in metabolic rate, body temperature and physiological functions. Studies have shown that animals in hibernation can resist neurological damage. Here, we aimed to study whether hypoxia can induce a hibernation-like state in a traditionally non-hibernating animal and whether it is neuroprotective. All procedures were conducted according to international guidelines on laboratory animal safety. Mice C57BL/6 (19-21g) were placed into a 125 mL jar with fresh air and the jar was sealed with a rubber plug. For each run, the tolerance limit was judged by the animals' appearance for "air hunger". The animal was removed from the jar as soon as its first gasping breath appeared and was moved to another fresh-air-containing jar of similar volume. This procedure was performed in four runs. The hypoxia exposure significantly decreased oxygen (O2) consumption, carbon dioxide (CO2) production, respiratory rate and heart rate. Meanwhile, rectal temperature reached a minimum of 12.7+/-2.56 degrees C, which is lower than a wide range of ambient temperatures. The mimicked hibernation decreased the infarct size in a focal cerebral ischemia mouse model. Our findings suggest the possibility of inducing suspended animation-like hibernation states for medical applications post injury.
dc.description.sponsorshipThis work was supported by the National Key R&D Program of China (2017YFC1308402) and Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX 201706).
dc.identifier.citationRen, C., Li, S., Rajah, G., Shao, G., Lu, G., Han, R., Huang, Q., Li, H., Ding, Y., Jin, K., & Ji, X. (2018). Hypoxia, hibernation and Neuroprotection: An Experimental Study in Mice. Aging and disease, 9(4), 761-768. https://doi.org/10.14336/AD.2018.0702
dc.identifier.issn2152-5250
dc.identifier.issue4
dc.identifier.urihttps://hdl.handle.net/20.500.12503/31698
dc.identifier.volume9
dc.publisherJKL International
dc.relation.urihttps://doi.org/10.14336/AD.2018.0702
dc.rights.holder© 2018 Ren C et al.
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceAging and Disease
dc.subjectclinical application
dc.subjecthibernation
dc.subjecthypothermia
dc.subjecthypoxia
dc.titleHypoxia, hibernation and Neuroprotection: An Experimental Study in Mice
dc.typeArticle
dc.type.materialtext

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