The Impact of Travel Stressors on the Pathogenesis of Autoimmunity in Female Lupus Mice

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dc.contributor.advisorMathis, Keisa W.
dc.contributor.committeeMemberMa, Rong
dc.contributor.committeeMemberCunningham, J. Thomas
dc.contributor.committeeMemberBasha, Riyaz
dc.creatorDinh, Viet Q.
dc.date.accessioned2023-07-14T21:00:37Z
dc.date.available2023-07-14T21:00:37Z
dc.date.issued2022-05
dc.description.abstractPreliminary studies found that an established model of systemic lupus erythematosus, the female NZBWF1 mouse, developed heightened disease severity later in life when shipped to UNTHSC during summer due to travel stressors. We hypothesized that this was partly due to early life stress that the mice experienced, and that eliminating these stressors will attenuate disease severity. We measured biomarkers of disease severity in NZBWF1 mice that were shipped as adults and compared with mice that were shipped in early life along with mice that were not shipped at all. We found that long-term biomarkers were higher in adult travel mice compared to early life travel mice, that these biomarkers were higher in summer mice compared to winter mice, and that non-travelling mice had the highest levels. Our findings indicate that adulthood stress exacerbates disease progression in NZBWF1 mice, and that seasonal factors impacted lupus pathogenesis in these adult mice.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/32377
dc.language.isoen
dc.subjectsystemic lupus erythematosus
dc.subjectstress
dc.subjectearly life stress
dc.subjectadverse childhood experiences
dc.subjectseasonal stress
dc.subject.meshLupus Erythematosus, Systemic
dc.subject.meshAdverse Childhood Experiences
dc.subject.meshStress, Physiological
dc.titleThe Impact of Travel Stressors on the Pathogenesis of Autoimmunity in Female Lupus Mice
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentSchool of Biomedical Sciences
thesis.degree.disciplineBiomedical Sciences
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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