Statins and PCSK9 Inhibitors: How They Have Shaped Medicine, A Comparative Review

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dc.contributor.advisorRustin E. Reeves
dc.contributor.committeeMemberPatricia A. Gwirtz
dc.creatorEscarsega, Phillip R.
dc.date.accessioned2019-08-22T20:09:13Z
dc.date.available2019-08-22T20:09:13Z
dc.date.issued2016-12-01
dc.date.submitted2017-05-08T07:12:06-07:00
dc.description.abstractKeeping serum low density lipoprotein cholesterol (LDL-C) levels within recommended ranges has been proven to lower the risk of cardiovascular events from occurring. To lower LDL-C levels, statins have been the drug of choice for the last few decades since they were introduced. However, the discovery of PCSK9 inhibitors and new knowledge about how they are able to lower LDL-C levels may provide physicians a new path to consider when choosing a course of treatment in patients that fit the criteria for PCSK9 inhibition. Furthermore, there are several risks with statins which may turn physicians towards using PCSK9 inhibitors in patients with uncontrolled LDL-C. This practicum report is a review of the latest developments in PCSK9 drugs and how they compare to statins in lowering LDL levels.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/27924
dc.language.isoen
dc.provenance.legacyDownloads62
dc.subjectAmino Acids, Peptides, and Proteins
dc.subjectChemical Actions and Uses
dc.subjectLipids
dc.subjectPCSK9
dc.subjectInhibitor
dc.subjectStatin
dc.subjectLipid
dc.subjectLDL
dc.subjectCVD
dc.subjectcardiovascular disease
dc.subjecthypercholesterolemia
dc.titleStatins and PCSK9 Inhibitors: How They Have Shaped Medicine, A Comparative Review
dc.typeInternship Practicum Report
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineClinical Research Management
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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