Physiologic and Anatomic Changes in Carpal Tunnel Syndrome: Is Osteopathic Manipulative Treatment an Effective Non-Surgical Alternative Therapy?

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dc.contributor.advisorWilliams, Stuart
dc.contributor.committeeMemberCruser, des Anges
dc.contributor.committeeMemberStoll, Scott
dc.creatorWhite, Heath D.
dc.date.accessioned2019-08-22T21:38:57Z
dc.date.available2019-08-22T21:38:57Z
dc.date.issued2005-05-01
dc.date.submitted2014-04-09T06:36:22-07:00
dc.description.abstractWhite, Heath D., D.O., M.S. Physiologic and Anatomic Changes in Carpal Tunnel Syndrome: Is Osteopathic Manipulative Treatment an Effective Non-surgical Alternative Therapy? Master of Science (Clinical Research and Education – OMM), May 2005, 110 pp., 4 tables, 5 figures, references, 46 titles. Objective: Carpal tunnel syndrome (CTS), caused by compression of the median nerve within the carpal tunnel, has a prevalence that ranges between 0.53 and 16.3 with medical costs exceeding $2 billion annually. The goal of this clinical trial was to assess for physiologic and anatomic changes in CTS in response to OMT. Physiologic changes were measured with nerve conduction studies (NCS). Anatomic changes were measured with magnetic resonance imaging. Methods: This prospective, randomized, controlled, blinded clinical trial phased to evaluate 50 subjects randomized between two treatment groups, OMT and placebo sub-therapeutic ultrasound. Eligibility criteria included adults between 21 and 70 with a clinical diagnosis of CTS and increased conduction latency of the median nerve. Outcome measures were median motor and sensory conduction distal latencies. Subjects received six treatments. NCS were conducted at entry to the study (baseline), midpoint, and endpoint. Results: Thirty-seven of a planned 50 subjects were randomized to groups. Thirty-one subjects were included in the final data analysis. Preliminary analysis found no significant difference in NCS values over the three testing intervals. Evaluation for effect(s) of multiple treatment providers by analyzing the single treatment provider with the greatest number of subjects found significant improvement in some NCS values for the OMT group. This study was funded by the Osteopathic Research Center, and approved by the UNTHSC Institutional Review Board. Conclusions: The results of this preliminary analysis indicate the possibility for improvement of CTS with OMT, but no conclusive statements about the efficacy of OMT can be made. This preliminary study enabled us to identify multiple areas in the research design and methodology that may be improved, and provides the framework for future studies.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12503/29485
dc.language.isoen
dc.provenance.legacyDownloads0
dc.subjectAlternative and Complementary Medicine
dc.subjectDiseases
dc.subjectInvestigative Techniques
dc.subjectLife Sciences
dc.subjectMedical Physiology
dc.subjectMedicine and Health Sciences
dc.subjectMusculoskeletal System
dc.subjectOsteopathic Medicine and Osteopathy
dc.subjectOther Physiology
dc.subjectPhysiology
dc.subjectRehabilitation and Therapy
dc.subjectSomatic Bodywork and Related Therapeutic Practices
dc.subjectTherapeutics
dc.subjectPhysiologic
dc.subjectanatomic
dc.subjectchanges
dc.subjectcarpal tunnel syndrome
dc.subjectosteopathic manipulative treatment
dc.subjectnon-surgical alternative therapy
dc.subjectCTS
dc.subjectclinical trial
dc.subjectOMT
dc.subjectUNTHSC
dc.subjectOsteopathic Research Center
dc.subjectresearch design
dc.subjectmethodology
dc.titlePhysiologic and Anatomic Changes in Carpal Tunnel Syndrome: Is Osteopathic Manipulative Treatment an Effective Non-Surgical Alternative Therapy?
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentGraduate School of Biomedical Sciences
thesis.degree.disciplineClinical Research and Education: Osteopathic Manipulative Medicine
thesis.degree.grantorUniversity of North Texas Health Science Center at Fort Worth
thesis.degree.nameMaster of Science

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